Results 31 to 40 of about 43,956,264 (204)

Radical S-Adenosylmethionine Enzymes

Chemical Reviews, 2014
It was once widely held that nearly all reactions in biology were catalyzed via mechanisms involving paired electron species. Beginning approximately 40 years ago, this paradigm was repeatedly challenged as examples of enzymatic reactions involving ...
J. Broderick, Benjamin R. Duffus, Kaitlin S. Duschene, E. Shepard   +3 more
semanticscholar   +1 more source

S-adenosylmethionine Biosynthesis is a Targetable Metabolic Vulnerability of Cancer Stem Cells

Breast Cancer Research and Treatment, 2019
PurposeMany transformed cells and embryonic stem cells are dependent on the biosynthesis of the universal methyl-donor S-adenosylmethionine (SAM) from methionine by the enzyme MAT2A to maintain their epigenome.
E. Strekalova, D. Malin, Erin Weisenhorn, J. Russell, Dominik Hoelper, Aayushi Y. Jain, J. Coon, P. Lewis, V. Cryns   +8 more
semanticscholar   +1 more source

S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research

Journal of Clinical Psychiatry, 2017
Objective A systematic review on S-adenosylmethionine (SAMe) for treatment of neuropsychiatric conditions and co-morbid medical conditions. Data Sources Searches were conducted between 7/15/2015 and 9/28/2016 by combining search terms for SAMe (s ...
Anup Sharma, P. Gerbarg, T. Bottiglieri, Lila Massoumi, L. Carpenter, H. Lavretsky, P. Muskin, Richard P. Brown, D. Mischoulon   +8 more
semanticscholar   +1 more source

Daropeptide natural products [PDF]

Exploration of Drug Science
Cyclophane-containing peptides comprise an important group of macrocyclic peptides with unique structural properties and pharmaceutical relevance. Darobactin A is a ribosomally synthesized and post-translationally modified peptide (RiPP) antibiotic ...
Suze Ma, Sijia Guo, Wei Ding, Qi Zhang
doaj   +1 more source

Characterization of a Fungal Modular Polyketide Synthase System Reveals an Unusual Strategy for Polyketide Chain Initiation

Angewandte Chemie, EarlyView.
Fungal modular polyketide synthases (PKSs) remain largely unexplored. Functional characterization of the LasC/LasD assembly line established its role in strasseriolide C biosynthesis and suggested an unexpected strategy for chain initiation, in which a malonyl unit is transferred from the module 2 acyl carrier protein (ACP) domains to the loading ACP ...
Qiaolin Ji, Chao Peng, Shuhan He, Bin‐Tao Peng, Wei‐Guang Wang, Yudai Matsuda   +5 more
wiley   +2 more sources

A natural riboswitch scaffold with self-methylation activity

Nature Communications, 2021
In humans, protein methyltransferase is responsible for RNA methylation using S-adenosylmethionine as a methyl group donor. Here the authors report a self-methylation activity of a bacterial riboswitch.
Laurin Flemmich, Sarah Heel, Sarah Moreno, Kathrin Breuker, Ronald Micura   +4 more
doaj   +1 more source

Mycofactocin biosynthesis: modification of the peptide MftA by the radical S‐adenosylmethionine protein MftC

FEBS Letters, 2016
Mycofactocin is a putative, peptide derived, cofactor that is associated primarily with the Mycobacterium genera including the pathogen M. tuberculosis.
Bulat Khaliullin, P. Aggarwal, Michael Bubas, G. Eaton, S. Eaton, J. Latham   +5 more
semanticscholar   +3 more sources

AL398, A Novel NSUN6 Inhibitor, Attenuates Epithelial‐Mesenchymal Transition and Metastasis in Endometrial Cancer by Abrogating m5C‐Dependent Stabilization of Snail mRNA

Advanced Science, EarlyView.
Proposed molecular mechanism: NSUN6 catalyzes m5C methylation on Snail mRNA to enhance its stability, leading to Snail upregulation and EMT promotion. The first‐in‐class inhibitor AL398 suppresses endometrial cancer metastasis by targeting the NSUN6‐m5C‐Snail. axis. ABSTRACT Endometrial cancer (EC) constitutes a leading gynecologic malignancy for which
Xiangzhuan Zhao, Linlin Yang, Huanxiang Chen, Chenfeng Guo, Hongshen Lu, Ying Zhu, Xuanzhi Wang, Yang Li, Ruike Zhang, Zichong Huang, Yifang Chen, Keyu Jin, Zeduo Xu, Lingxiu Meng, Longfeng Zhang, Yuanyuan Han, Yicong Yan, Qiaozhen Kang, Junhu Wan, Hongyang Liu   +19 more
wiley   +1 more source

AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle

Nature Communications, 2018
Phosphatidylcholines (PC) and S-adenosylmethionine (SAM) are critical determinants of hepatic lipid levels, but how their levels are regulated is unclear.
Young-Chae Kim, Sunmi Seok, S. Byun, B. Kong, Yang Zhang, Grace L. Guo, Wen Xie, Jian Ma, B. Kemper, J. Kemper   +9 more
semanticscholar   +1 more source

FERONIA receptor kinase interacts with S-adenosylmethionine synthetase and suppresses S-adenosylmethionine production and ethylene biosynthesis in Arabidopsis.

Plant, Cell and Environment, 2015
Environmental inputs such as stress can modulate plant cell metabolism, but the detailed mechanism remains unclear. We report here that FERONIA (FER), a plasma membrane receptor-like kinase, may negatively regulate the S-adenosylmethionine (SAM ...
Dandan Mao, Feng Yu, Jian Li, B. Van de Poel, D. Tan, Jiang-Lin Li, Yanqionq Liu, Xiu-Shan Li, Mengqiu Dong, Liang-Bi Chen, Dong-Ping Li, Sheng Luan   +11 more
semanticscholar   +2 more sources