Results 11 to 20 of about 43,956,264 (204)
, 1989 Methylation studies of MBP and synthetic peptides by S-adenosylmethionine-MBP methyltransferase from bovine ...
Frida. Grynspan (7963835)
core +6 more sources
Redox Biology, 2020 Acute pancreatitis is an inflammatory process of the pancreatic gland that may lead to dysregulation of the trans-sulfuration pathway. The aims of this work were firstly to study the methionine cycle as well as the trans-sulfuration pathway using ...
Sergio Rius-Pérez +11 more
doaj +1 more source
Stable Isotope Dilution Assays for Clinical Analyses of Folates and Other One-Carbon Metabolites: Application to Folate-Deficiency Studies. [PDF]
PLoS ONE, 2016 Folate deficiency is generally accepted as a potential direct or indirect risk factor for diseases including spina bifida, coronary heart diseases, malfunctions of the central nervous system, and cancer. The direct inclusion of folates in the methylation
Markus Kopp +3 more
doaj +1 more source
Characterization of a Novel Putative S-Adenosylmethionine Decarboxylase-Like Protein from Leishmania donovani. [PDF]
PLoS ONE, 2013 In addition to the S-adenosylmethionine decarboxylase (AD) present in all organisms, trypanosomatids including Leishmania spp. possess an additional copy, annotated as the putative S-adenosylmethionine decarboxylase-like proenzyme (ADL).
Saurabh Pratap Singh +2 more
doaj +1 more source
Metabolites, 2022 S-adenosylmethionine (SAM) is essential for methyl transfer reactions. All SAM is produced de novo via the methionine cycle. The demethylation of SAM produces S-adenosylhomocysteine (SAH), an inhibitor of methyltransferases and the precursor of ...
Aida Corrillero Bravo +12 more
doaj +1 more source
S‐adenosylmethionine: A metabolite critical to the regulation of autophagy
Cell Proliferation, 2020 Autophagy is a mechanism that enables cells to maintain cellular homeostasis by removing damaged materials and mobilizing energy reserves in conditions of starvation.
Yang Ouyang +4 more
semanticscholar +1 more source
5-methyl-tetrahydrofolate and the S-adenosylmethionine cycle in C57BL/6J mouse tissues: gender differences and effects of arylamine N-acetyltransferase-1 deletion. [PDF]
PLoS ONE, 2013 Folate catabolism involves cleavage of the C(9)-N(10) bond to form p-aminobenzoylgluamate (PABG) and pterin. PABG is then acetylated by human arylamine N-acetyltransferase 1 (NAT1) before excretion in the urine.
Katey L Witham +5 more
doaj +1 more source
Proteogenomic characterization of cholangiocarcinoma
Hepatology, EarlyView., 2022 Proteogenomic characterization of cholangiocarcinoma with therapeutic strategies Abstract Background and Aims Cholangiocarcinoma (CCA) is a highly heterogeneous cancer with limited understanding and few effective therapeutic approaches. We aimed at providing a proteogenomic CCA characterization to inform biological processes and treatment ...
Mengjie Deng +18 more
wiley +1 more source
Definitions, 2020 A nutritional supplement that is synthesized from adenosine triphosphate (AT P) and the amino acid methionine by the endogenous essential enzyme methionine adenosyltransferase (MAT ), with potential antineoplastic activity.
semanticscholar +1 more source
Fluorinated S-adenosylmethionine as a reagent for enzyme-catalyzed fluoromethylation.
Angewandte Chemie, 2021 Strategic replacement of protons with fluorine atoms or functional groups with fluorine-containing fragments has proven a powerful strategy to optimize the activity of therapeutic compounds. For this reason, the synthetic chemistry of organofluorides has
Jiaming Peng +3 more
semanticscholar +1 more source