Results 11 to 20 of about 15,844,621 (256)

Associations of S-Adenosylmethionine and S-Adenosylhomocysteine with Hepatocellular Carcinoma [PDF]

Metabolites
Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide, increasingly arising in patients with metabolic dysfunction-associated steatotic liver disease (MASLD).
Naana N. Yalley, Sebastian M. Armasu, Winnie Z. Fan, Irene K. Yan, Fowsiyo Y. Ahmed, Per Stål, Lewis R. Roberts, Tushar Patel, Samuel O. Antwi   +8 more
doaj   +2 more sources

Excess S-adenosylmethionine inhibits methylation via catabolism to adenine [PDF]

Communications Biology, 2022
S-adenosylmethionine (SAM) is a widely available dietary supplement. Exogenous SAM is catabolized to adenine, an inhibitor of adenosylhomocysteinase, leading to widespread methylation inhibition and disruption of circadian rhythms in vitro and in mice.
Kazuki Fukumoto, Kakeru Ito, Benjamin Saer, George Taylor, Shiqi Ye, Mayu Yamano, Yuki Toriba, Andrew Hayes, Hitoshi Okamura, Jean-Michel Fustin   +9 more
doaj   +2 more sources

Characterization of a Novel Putative S-Adenosylmethionine Decarboxylase-Like Protein from Leishmania donovani. [PDF]

PLoS ONE, 2013
In addition to the S-adenosylmethionine decarboxylase (AD) present in all organisms, trypanosomatids including Leishmania spp. possess an additional copy, annotated as the putative S-adenosylmethionine decarboxylase-like proenzyme (ADL).
Saurabh Pratap Singh, Pragati Agnihotri, J Venkatesh Pratap   +2 more
doaj   +3 more sources

Interplay of serum taurine, S-adenosylmethionine, and cysteine levels in cancer risk: a prospective study [PDF]

Frontiers in Pharmacology
BackgroundAmino acids are known to play critical roles in cancer metabolism and progression. Among them, taurine, S-adenosylmethionine (SAM), and cysteine have garnered particular attention due to their interconnected metabolic pathways.
Chenan Liu, Chenan Liu, Chenan Liu, Chenan Liu, Chenan Liu, Tong Liu, Tong Liu, Tong Liu, Tong Liu, Tong Liu, Yaping Wei, Jinyu Shi, Jinyu Shi, Jinyu Shi, Jinyu Shi, Jinyu Shi, Li Deng, Li Deng, Li Deng, Mengmeng Song, Hanping Shi, Hanping Shi, Hanping Shi, Hanping Shi, Hanping Shi   +24 more
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(S)–S-adenosylmethionine in the treatment of pre-menstrual disorders in adult women: A protocol for an open-label pilot study [PDF]

Contemporary Clinical Trials Communications
Pre-menstrual disorders, including pre-menstrual syndrome and pre-menstrual dysphoric disorder, are highly prevalent disorders in women of reproductive age. Pre-menstrual disorders are associated with debilitating symptoms that onset in the days prior to
Brendan Stevenson, Emorfia Gavrilidis, Yasmin Malik, Jayashri Kulkarni   +3 more
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S-Adenosylmethionine May Mitigate Obstructive Sleep Apnea in an Adult with Down Syndrome: A Case Report [PDF]

Nature and Science of Sleep, 2022
Silvano Dragonieri,1 Giovanna Elisiana Carpagnano,1 Salvatore Caccamese2 1Department of Respiratory Diseases, University of Bari, Bari, Italy; 2Department of Chemical Sciences, University of Catania, Catania, ItalyCorrespondence: Silvano ...
Dragonieri S, Carpagnano GE, Caccamese S
doaj   +2 more sources

S‐adenosylmethionine and nicotinamide riboside therapy in Arts syndrome: A case report and literature review [PDF]

JIMD Reports, 2023
Phospho‐ribosyl‐pyrophosphate synthetase 1 (PRPS1) deficiency is secondary to loss of function variants in PRPS1. This enzyme generates phospho‐ribosyl‐pyrophosphate (PRPP), which is utilized in the synthesis of purines, nicotinamide adenine dinucleotide
Angela Lee, Renatta Knox, Margaret Reynolds, Erin McRoy, Hoanh Nguyen   +4 more
doaj   +2 more sources

Engineered reduction of S-adenosylmethionine alters lignin in sorghum [PDF]

Biotechnology for Biofuels and Bioproducts
Background Lignin is an aromatic polymer deposited in secondary cell walls of higher plants to provide strength, rigidity, and hydrophobicity to vascular tissues.
Yang Tian, Yu Gao, Halbay Turumtay, Emine Akyuz Turumtay, Yen Ning Chai, Hemant Choudhary, Joon-Hyun Park, Chuan-Yin Wu, Christopher M. De Ben, Jutta Dalton, Katherine B. Louie, Thomas Harwood, Dylan Chin, Khanh M. Vuu, Benjamin P. Bowen, Patrick M. Shih, Edward E. K. Baidoo, Trent R. Northen, Blake A. Simmons, Robert Hutmacher, Jackie Atim, Daniel H. Putnam, Corinne D. Scown, Jenny C. Mortimer, Henrik V. Scheller, Aymerick Eudes   +25 more
doaj   +2 more sources

Impact of sevoflurane anesthesia on S-adenosylmethionine in neonates under general anesthesia [PDF]

Journal of Anaesthesiology Clinical Pharmacology
Background and Aims: Preclinical studies in rodents and primates have shown that anesthesia was neurotoxic to the developing brain after exposure in the neonatal period. Sevoflurane a commonly used inhalational anesthetic, especially in pediatric surgery,
Saraswathi Nagappa, Sandhya Kalappa, Raghavendra B. Sridhara, Dayananda S. Biligi, R Annapoorneshwari, Ramachandraiah   +5 more
doaj   +2 more sources

Cysteine Restriction Induces Ferroptosis Depending on the S-adenosylmethionine and Polyamine Biosynthetic Pathways in Hepatic Cancer Cells [PDF]

Gastro Hep Advances
Background and Aims: Liver diseases such as hepatocellular carcinoma are known to be affected by nutrition and metabolic activities, but the mechanisms behind them remain unclear.
Keisuke Tada, Kazuki Mitsuyama, Hironari Nishizawa, Hiroki Shima, Akihiko Muto, Motoshi Wada, Daisuke Saigusa, Kazuhiko Igarashi   +7 more
doaj   +2 more sources