Results 91 to 100 of about 15,844,621 (256)

Inactivation and dissociation of s-adenosylmethionine synthetase by modification of sulfhydryl groups and its possile occurrence in cirrhosis [PDF]

, 2013
Catalytically active human and rat liver S-adenosylmethionine synthetase exists mainly in tetramer and dimer form. In liver biopsy samples from cirrhotic patients a marked reduction in total S-adenosylmethionine synthetase activity and a specific loss of
Pajares, María Ángeles, Martín-Duce, Antonio, Mato, José M., Corrales, Fernando J., Cabrero, Carmen, Ortiz, Pablo   +5 more
core   +1 more source

Structure and regulation of mammalian S-adenosylmethionine decarboxylase [PDF]

, 1988
In order to understand the structure and regulation of S-adenosylmethionine decarboxylase, cDNA clones encoding this enzyme have been isolated from rat prostate and human fibroblast cDNA libraries.
Madhubala, R., Janne, O. A., Laitinen, P. H., Stanley, B., Crozat, A., Pajunen, A., Pegg, A. E., Ihalainen, R.   +7 more
core   +3 more sources

Vitamin B12-impaired metabolism produces apoptosis and Parkinson phenotype in rats expressing the transcobalamin-oleosin chimera in substantia nigra.

PLoS ONE, 2009
BackgroundVitamin B12 is indispensable for proper brain functioning and cytosolic synthesis of S-adenosylmethionine. Whether its deficiency produces effects on viability and apoptosis of neurons remains unknown.
Carlos Enrique Orozco-Barrios, Shyue-Fang Battaglia-Hsu, Martha Ligia Arango-Rodriguez, Jose Ayala-Davila, Celine Chery, Jean-Marc Alberto, Henry Schroeder, Jean-Luc Daval, Daniel Martinez-Fong, Jean-Louis Gueant   +9 more
doaj   +1 more source

UTILIZATION OF S-ADENOSYLMETHIONINE BY MICROORGANISMS [PDF]

Journal of Bacteriology, 1962
Shapiro, Stanley K. (Argonne National Laboratory, Argonne, Ill.). Utilization of S-adenosylmethionine by microorganisms. J. Bacteriol. 83: 169–174. 1962.—Two types of mutants of Aerobacter aerogenes that utilize S-adenosylmethionine for growth are described. One type also responds
openaire   +2 more sources

Associations Between Microbial Depletion and Autonomic Dysregulation in Binge‐Eating Disorder

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective The interplay between the gut microbiome and autonomic nervous system remains unexplored in binge‐eating disorder (BED). We aimed to explore specific microbial alterations in BED and examine their potential association with cardiac vagal tone as a distinct bio‐behavioral phenotype.
Shuang Liang, Esben Strodl, Leanne Barron, Matthew Bambling, Luis Vitetta   +4 more
wiley   +1 more source

Non-alcoholic fatty liver disease and cognitive impairment [PDF]

Терапевтический архив
Aim. To evaluate the efficacy of oral administration of the original ademetionine (Geptral) at a dose of 1500 mg/s in patients with NAFLD at the steatosis stage and cognitive impairment within the framework of a prospective observational open non ...
Elena V. Onuchina, Bairma B. Dambaeva, Anna G. Glazunova, Ayuna Kh. Mikhailova, Elena M. Vorobyova, Elena I. Soshina, Natalya V. Efremenko   +6 more
doaj   +1 more source

How tissue damage MET metabolism: Regulation of the systemic damage response

Fly, 2017
Living organisms experience tissue damage from both, the surrounding environment and from inside their bodies. Tissue repair/regeneration is triggered by local tissue injury to restore an injured, or lost, part of the body.
Soshiro Kashio, Fumiaki Obata, Masayuki Miura   +2 more
doaj   +1 more source

Second‐trimester multimetabolite panel for early preeclampsia rule‐out

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective We aimed to establish a high‐sensitivity, multimetabolite rule‐out model for the development of preeclampsia (PE), prioritizing minimizing false negatives to exclude low‐risk individuals from intensive surveillance confidently. Methods In this prospective, nested case–control study, maternal serum samples were collected between 20+0 ...
Matthews Silva Martins, Julyane N. S. Kaihara, Diego Fortes Salgueiro, Viviane Cunha Cardoso, Silvana Maria Quintana, Ricardo Carvalho Cavalli, Valerio Garrone Barauna, Valeria Cristina Sandrim   +7 more
wiley   +1 more source

Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine [PDF]

, 2018
S-adenosylmethionine (SAM) is a donor which provides the methyl groups for histone or nucleic acid modification and phosphatidylcholine production.
Amy K Walker, Daniel P Higgins, Daniel P. Higgins (6018590), Wei Ding (690), Read Pukkila-Worley (159543), Amy K. Walker (6018599), Dilip K Yadav, Dilip K. Yadav (6018593), Adwait A. Godbole (6018596), Wei Ding, Adwait A Godbole, Read Pukkila-Worley   +11 more
core   +1 more source

Metabolic engineering of Bacillus amyloliquefaciens for enhanced production of S-adenosylmethionine by coupling of an engineered S-adenosylmethionine pathway and the tricarboxylic acid cycle

Biotechnology for Biofuels, 2019
Background S-Adenosylmethionine (SAM) is a critical cofactor involved in many biochemical reactions. However, the low fermentation titer of SAM in methionine-free medium hampers commercial-scale production.
Liying Ruan, Lu Li, Dian Zou, Cong Jiang, Zhiyou Wen, Shouwen Chen, Yu Deng, Xuetuan Wei   +7 more
doaj   +1 more source