Results 111 to 120 of about 15,844,621 (256)

The efficiency of metabolic impact of S-adenosylmethionine and meldonium on parameters of lipid profile and insulin resistance during comorbid course of nonalcocholic steatohepatitis, obesity and chronic kidney disease stage І-ІІ

Zaporožskij Medicinskij Žurnal, 2018
Objective – to investigate the influence of the complex of S-adenosylmethionine (Agepta) and meldonium (Vasonat) on the course of NASH with obesity and CKD, the state of the lipid profile of the blood, and the degree of insulin resistance.
O. S. Khukhlina, A. A. Antoniv, O. S. Voievidka, O. B. Kuzminska   +3 more
doaj   +1 more source

MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy

Cancer Science, EarlyView.
MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Hiroaki Ikushima, Hidenori Kage
wiley   +1 more source

DNA methylation regulates expression of VEGF-C, and S-adenosylmethionine is effective for VEGF-C methylation and for inhibiting cancer growth

Brazilian Journal of Medical and Biological Research, 2014
DNA hypomethylation may activate oncogene transcription, thus promoting carcinogenesis and tumor development. S-adenosylmethionine (SAM) is a methyl donor in numerous methylation reactions and acts as an inhibitor of intracellular demethylase activity ...
M.X. Da, Y.B. Zhang, J.B. Yao, Y.X. Duan
doaj   +1 more source

Enzymatic Cleavage of S-Adenosylmethionine

Journal of Biological Chemistry, 1959
S-adenosylmethionine, known for some time to be the biological methyl donor in mammalian enzymatic transmethylation reactions (1,2), has more recently been implicated in other transalkylation reactions in bacteria and yeast (3-6). The enzyme system catalyzing the condensation of ATP and methionine to form AMe’ has been found in a variety of tissues and
openaire   +2 more sources

S‐Adenosylmethionine (SAM) hydrolases counter increased SAM epimerisation in thermophilic archaea

The FEBS Journal, EarlyView.
S‐Adenosyl‐l‐methionine (SAM) is a vital enzyme cofactor. Epimerisation at the sulfonium centre of biologically active (SS,SCα)‐SAM is driven by heat, yielding biologically inactive (RS,SCα)‐SAM. Here, two novel archaeal SAM hydrolases from the thermophilic Sulfolobus acidocaldarius and the halophilic Haloferax volcanii are shown to cleave (RS,SCα)‐SAM.
Agnes Bartels, Michael K. F. Mohr, Phillip Nußbaum, Marie Joest, Bianca Wassmer, Laurent Rasquin, Sonja‐Verena Albers, Jennifer N. Andexer   +7 more
wiley   +1 more source

Reductive cleavage of S-adenosylmethionine by biotin synthase from Escherichia coli [PDF]

, 2002
Biotin synthase (BioB) catalyzes the insertion of a sulfur atom between the C6 and C9 carbons of dethiobiotin. Reconstituted BioB from Escherichia coli contains a [4Fe-4S](2+/1+) cluster thought to be involved in the reduction and cleavage of S ...
Ollagnier-de Choudens, Sandrine, Sanakis, Yiannis, Roach, Peter, Münck, Eckard, Fontecave, Marc, Hewitson, Kirsty S.   +5 more
core   +1 more source

Toward understanding the catalytic mechanism for two classes of bacterial phospholipid N‐methyltransferases

The FEBS Journal, EarlyView.
Phospholipid N‐methyltransferases (Pmts) synthesize phosphatidylcholine in many bacteria. In this study, we compared the catalytic mechanisms of two bacterial Pmt classes: the Rhodobacter (R‐) and the Sinorhizobium (S‐) type. Representative enzymes for each class were derived from Rubellimicrobium thermophilum and Agrobacterium tumefaciens ...
Irina Shevyreva, Lena Sophie Fritsch, Leander Mika Koch, Anton Effing, Meriyem Aktas, Franz Narberhaus   +5 more
wiley   +1 more source

The epigenetic landscape of skeletal muscle in response to exercise and aging

The FEBS Journal, EarlyView.
Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley   +1 more source

Effect of S-adenosylmethionine on human rotavirus RNA synthesis [PDF]

, 1984
The characteristics of human rotavirus-associated RNA polymerase activity have been examined in relation to the effects of ribonucleoside triphosphate analogs and S-adenosylmethionine.
GARCIA,, Spencer, Nicolás
core  

Methotrexate-associated biochemical alterations in a patient with chronic neurotoxicity [PDF]

Journal of Medical Biochemistry, 2009
Intrathecal and/or high-dose intravenous administration of methotrexate (MTX) in the treatment of malignancies such as acute lymphoblastic leukaemia (ALL) has been associated with cases of mild to severe neurotoxicity.
Vezmar Sandra, Bode Udo, Jaehde Ulrich
doaj