Results 101 to 110 of about 43,956,264 (204)

Fresh Insights Into SLC25A26: Potential New Therapeutic Target for Cancers: A Review

Oncology Reviews
SLC25A26 is the only known human mitochondrial S-adenosylmethionine carrier encoding gene. Recent studies have shown that SLC25A26 is abnormally expressed in some cancers, such as cervical cancer, low-grade glioma, non-small cell lung cancer, and liver ...
Yangheng Xu, Zhisheng Hong, Sheng Yu, Ronghan Huang, Kunqi Li, Ming Li, Sisi Xie, Lvyun Zhu   +7 more
doaj   +1 more source

DNA methylation regulates expression of VEGF-C, and S-adenosylmethionine is effective for VEGF-C methylation and for inhibiting cancer growth

Brazilian Journal of Medical and Biological Research, 2014
DNA hypomethylation may activate oncogene transcription, thus promoting carcinogenesis and tumor development. S-adenosylmethionine (SAM) is a methyl donor in numerous methylation reactions and acts as an inhibitor of intracellular demethylase activity ...
M.X. Da, Y.B. Zhang, J.B. Yao, Y.X. Duan
doaj   +1 more source

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source

Algorithm of management of patient with alcohol-induced liver disease

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2011
The aim of review. To present main pathogenic aspects of development of alcohol-induced liver disease (ALD), principles of diagnostics and treatment of this disease.Original positions.
M. V. Mayevskaya, M. A. Morozova
doaj  

The efficiency of metabolic impact of S-adenosylmethionine and meldonium on parameters of lipid profile and insulin resistance during comorbid course of nonalcocholic steatohepatitis, obesity and chronic kidney disease stage І-ІІ

Zaporožskij Medicinskij Žurnal, 2018
Objective – to investigate the influence of the complex of S-adenosylmethionine (Agepta) and meldonium (Vasonat) on the course of NASH with obesity and CKD, the state of the lipid profile of the blood, and the degree of insulin resistance.
O. S. Khukhlina, A. A. Antoniv, O. S. Voievidka, O. B. Kuzminska   +3 more
doaj   +1 more source

The TaCOMT1A‐Synthesised Sakuranetin Is a Novel Biostimulant Enhancing Drought Tolerance and Yield in Wheat

Plant Biotechnology Journal, EarlyView.
ABSTRACT Drought stress is a major limitation to global wheat production. Here, we demonstrate that the wheat gene TaCOMT1A, encoding a caffeic acid O‐methyltransferase, plays a crucial role in enhancing drought tolerance in wheat. Overexpression of TaCOMT1A significantly improved drought tolerance at the seedling stage, as evidenced by higher survival
Mingzhao Luo, Chengjie Xu, Wenjing Yang, Wensi Tang, Kai Chen, Jiaqing Guo, Qiyu Wang, Jun Chen, Zhaoshi Xu, Pierre Delaplace, Youzhi Ma, Yongbin Zhou, Ming Chen   +12 more
wiley   +1 more source

Strong cellular preference in the expression of a housekeeping gene of Arabidopsis thaliana encoding S-adenosylmethionine synthetase [PDF]

, 1989
S-Adenosylmethionine serves as a methyl group donor in numerous transmethylation reactions and plays a role in the biosynthesis of polyamines and ethylene.
Seurinck, Jef, G Engler, Peleman, Johan, W Boerjan, Inzé, Dirk, Van Montagu, Marc, J Seurinck, J Peleman, Botterman, Johan, J Botterman, T Alliotte, Alliotte, Thierry, M Van Montagu, Engler, Gilbert, Boerjan, Wout, D Inzé   +15 more
core   +1 more source

s-adenosylmethionine levels govern innate immunity through distinct methylation-dependent pathways

Cell Metabolism, 2015
Summary s-adenosylmethionine (SAM) is the sole methyl donor modifying histones, nucleic acids and phospholipids. Its fluctuation impacts hepatic phosphatidylcholine (PC) synthesis or may be linked to variations in DNA or histone methylation ...
Wei Ding, Lorissa J. Smulan, Nicole S. Hou, S. Taubert, J. Watts, A. Walker   +5 more
semanticscholar   +1 more source

Single‐Cell Transcriptomics Reveals the FA9–VAP Module Regulating Fatty Acid Accumulation in Soybean Seeds

Plant Biotechnology Journal, EarlyView.
ABSTRACT As a major commercial legume crop, soybean ranks among the world's most significant sources of edible oil and plant protein. We previously identified a SEIPIN homologue (FA9) at the fatty acid 9 locus that promotes fatty acid accumulation in soybean.
Hui Li, Tianshu Li, Xiaorui Xu, Jinhang Cui, Xin Chen, Jingyi Huang, Jia Song, Cui Mu, Xinyu Hong, Chunyan Liu, Ning Wang, Xue Han, Sui Wang, Qingshan Chen, Zhaoming Qi   +14 more
wiley   +1 more source

Purification and characterization of s-adenosylmethionine synthetase from candida albicans

, 1989
S-Adenosylmethionine (SAM) synthetases isolated from both the yeast and hyphal-phase of the dimorphic fungus, C. albicans, were partially purified using DEAE cellulose ion-exchange column chromatography.
Jones, Ward M.
core