Results 81 to 90 of about 43,956,264 (204)

METTL7B Expression in Sepsis: Association With Disease Severity and 28‐Day Mortality

Journal of Clinical Laboratory Analysis, EarlyView.
This prospective cohort study demonstrates that whole blood METTL7B expression is significantly elevated in sepsis patients upon ICU admission and independently associates with disease severity and 28‐day mortality. METTL7B alone predicted 28‐day mortality with an AUC of 0.779, and its combination with dynamic SOFA score and PCT achieved the highest ...
Yuxuan Zhang, Yonghua Wang, Mengjiao Yang, Dan Huang   +3 more
wiley   +1 more source

How tissue damage MET metabolism: Regulation of the systemic damage response

Fly, 2017
Living organisms experience tissue damage from both, the surrounding environment and from inside their bodies. Tissue repair/regeneration is triggered by local tissue injury to restore an injured, or lost, part of the body.
Soshiro Kashio, Fumiaki Obata, Masayuki Miura   +2 more
doaj   +1 more source

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source

EFFECT OF S-ADENOSYLMETHIONINE ON HEPATIC AND METABOLIC DISORDERS IN GUINEA PIGS WITH NONALCOHOLIC STEATOHEPATITIS

İstanbul Tıp Fakültesi Dergisi
Objective: S-adenosylmethionine (SAM) has antioxidant and anti-inflammatory actions and hepatoprotective potential. In this study, the therapeutic effectiveness of SAM was investigated in high-fat/cholesterol diet (HFCD)-induced non-alcoholic ...
İlknur Bingül, Canan Küçükgergin, Abdurrahman Fatih Aydın, Aydın Çevik, Merva Soluk Tekkeşin, Necat Vakur Olgaç, Semra Doğru Abbasoğlu, Mehmet Müjdat Uysal   +7 more
doaj   +1 more source

Non-alcoholic fatty liver disease and cognitive impairment [PDF]

Терапевтический архив
Aim. To evaluate the efficacy of oral administration of the original ademetionine (Geptral) at a dose of 1500 mg/s in patients with NAFLD at the steatosis stage and cognitive impairment within the framework of a prospective observational open non ...
Elena V. Onuchina, Bairma B. Dambaeva, Anna G. Glazunova, Ayuna Kh. Mikhailova, Elena M. Vorobyova, Elena I. Soshina, Natalya V. Efremenko   +6 more
doaj   +1 more source

Proteo‐transcriptomic insights into the venom composition of the ectoparasitoid Eupelmus urozonus

Pest Management Science, EarlyView.
Integrated venom‐gland transcriptomics and venom proteomics of Eupelmus urozonus identified 316 venom proteins, including 75 secreted candidates, revealing diverse hydrolases, proteases/inhibitors and many uncharacterized effectors. Abstract BACKGROUND Ectoparasitoid venoms are ‘cocktails’ of bioactive molecules injected during oviposition to paralyze ...
Federica De Stefano, Carmen Scieuzo, Rosanna Salvia, Riccardo Moretti, Flora Cozzolino, Maria Monti, Heiko Vogel, Patrizia Falabella   +7 more
wiley   +1 more source

Streamlined recycling of S-adenosylmethionine

, 2019
S-adenosylmethionine (SAM)-dependent methyltransferase enzymes have significant synthetic potential, but their utility as biocatalysts has been limited by the availability of SAM. An elegant and simple method addressing this long-standing problem has now
Micklefield, Jason
core   +1 more source

Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans

Nutrition & Diabetes, 2016
Background:Plasma concentration of the methyl donor S-adenosylmethionine (SAM) is linearly associated with body mass index (BMI) and fat mass. As SAM is a high-energy compound and a sensor of cellular nutrient status, we hypothesized that SAM would ...
Ak Elshorbagy, F. Jernerén, D. Samocha-Bonet, H. Refsum, L. Heilbronn   +4 more
semanticscholar   +1 more source

Natural Polysaccharides for Rheumatoid Arthritis Therapy: Mechanism, Drug Delivery and Clinical Application

Phytotherapy Research, EarlyView.
Schematic overview of the experimental models, therapeutic mechanisms, drug delivery systems, and clinical potential of natural polysaccharides in rheumatoid arthritis. ABSTRACT Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized primarily by chronic synovitis.
Luxin Li, Junnan Li, Guangzhi Li, Lili Huang, Tiantian Wen, Yanying Li, Yan Sun, Zhenqiang Liu, Qingshan Chen, Lili Zhang, Tiangang Lu, Ruiyan Wu, Haixue Kuang, Xiaochi Ma, Yan Liu   +14 more
wiley   +1 more source

S-adenosylmethionine inhibits ubiquitin-proteasome system in vitro and on rat vascular smooth muscle cells

, 2008
S-adenosylmethionine is a metabolite regulating many biological processes; S-adenosylmethionine effect on ubiquitin-proteasome system (UPS) has not been studied yet. We investigated S-adenosylmethionine effects on UPS activity both in vitro, by inhibitor
BIZZARRI, Mariano, CAVALLARO, Antonino, Cucina, Alessandra, D'ANSELMI, FABRIZIO, SCARPA, Sigfrido, FUSO, ANDREA, Cavallaro, Rosaria Adele, Cavallaro, Giuseppe   +7 more
core   +1 more source