Results 81 to 90 of about 15,844,621 (256)
Angewandte Chemie International Edition, EarlyView.A non‐canonical C16 sesquiterpene synthase from Morganella morganii produces the unusual scaffold descartane. Its cyclisation mechanism was rationalised by isotopic labelling experiments and DFT calculations. Site‐directed mutagenesis altered enzyme function, resulting in alternative products, including voltairene, which requires a different ...
Kexin Yang +4 more
wiley +1 more source
Evaluation of chemical and diastereoisomeric stability of S-adenosylmethionine in aqueous solution by capillary electrophoresis [PDF]
, 2005 Capillary electrophoresis was used for monitoring the stability of S-adenosylmethionine in aqueous solution under different conditions of storage and incubation used for "in vitro" and "in vivo" experiments, by evaluating both the entity of degradation ...
Claudia Desiderio +5 more
core +1 more source
İstanbul Tıp Fakültesi DergisiObjective: S-adenosylmethionine (SAM) has antioxidant and anti-inflammatory actions and hepatoprotective potential. In this study, the therapeutic effectiveness of SAM was investigated in high-fat/cholesterol diet (HFCD)-induced non-alcoholic ...
İlknur Bingül +7 more
doaj +1 more source
Parasite, 2005 Biological effects of piroxicam, metamizol, and S-adenosylmethionine (S-AMET) have been tested in NMRI mice infected intraperitoneally with Trichomonas vaginalis. An intraperitoneal treatment during ten preinfection days with piroxicam (10 mg/Kg/day), or
Nogal-Ruiz J.J. +4 more
doaj +1 more source
Acute ethanol-induced liver injury is prevented by betaine administration
Frontiers in Physiology, 2022 Binge drinking is the most common form of excessive alcohol use. Repeated episodes of binge drinking cause multiple organ injuries, including liver damage.
Madan Kumar Arumugam +19 more
doaj +1 more source
Angewandte Chemie International Edition, EarlyView.CYB5R3 is identified as a putative electron‐transfer partner of viperin (RSAD2), explaining why ER localisation is required for antiviral activity. Its utilisation enabled the engineering of immune‐silent, catalytically self‐sufficient antiviral restriction factor enzymes (iCAREs) that produce an antiviral nucleoside triphosphate analogue (ANTA ...
Mengdi Wu +16 more
wiley +1 more source
Cysteine Methylation Controls Radical Generation in the Cfr Radical AdoMet rRNA Methyltransferase [PDF]
, 2013 The 'radical S-adenosyl-L-methionine (AdoMet)' enzyme Cfr methylates adenosine 2503 of the 23S rRNA in the peptidyltransferase centre (P-site) of the bacterial ribosome.
Driesener, RC +17 more
core +1 more source
Vitamin B12 impacts amyloid-β induced proteotoxicity by regulating the methionine/S-adenosylmethionine cycle [PDF]
, 2021 Original, unprocessed data for Lam, A.B., Kervin, K., and Tanis, J.E. (2021) Vitamin B12 impacts amyloid-β induced proteotoxicity by regulating the methionine/S-adenosylmethionine ...
Tanis, J (via Mendeley Data)
core +1 more source
Enhanced strategies for cuproptosis‐like death in bacterial infection treatment
BMEMat, EarlyView.This review summarizes and examines the molecular mechanisms underlying cuproptosis‐like death. Furthermore, multi‐strategy efficacy enhancement and potential enhancement approaches are analyzed. Abstract Copper, a classical antibacterial metal, has long been of interest and widely used in medical and public health applications.
Wenqi Wang +7 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.An electrophilic 5‐isothiocyanatomethyl uridine building block enables modular post‐synthetic RNA labeling with primary amine‐containing probes. Positioning the functionality in the major groove minimizes structural perturbation and allows facile conjugation of sensitive tags such as TEMPO spin labels for paramagnetic relaxation enhancement studies ...
Lisa Ruetz +4 more
wiley +1 more source