Results 71 to 80 of about 122,610 (155)

Oncogenic PI3K promotes methionine dependency in breast cancer cells through the cystine-glutamate antiporter xCT

Science Signaling, 2017
Inhibition of the transporter xCT by oncogenic PI3K mutants contributes to methionine dependency in breast cancer cells. Understanding the causes of methionine dependency Cells can use the same precursor to produce either methionine or cysteine, but can ...
Evan C. Lien, L. Ghisolfi, Renee C. Geck, J. Asara, A. Toker   +4 more
semanticscholar   +1 more source

Methionine Metabolism Alters Oxidative Stress Resistance via the Pentose Phosphate Pathway

Antioxidants and Redox Signaling, 2016
Nutrient uptake and metabolism have a significant impact on the way cells respond to stress. The amino acid methionine is, in particular, a key player in the oxidative stress response, and acting as a reactive oxygen species scavenger, methionine is ...
Kate Campbell, J. Vowinckel, M. Keller, M. Ralser   +3 more
semanticscholar   +1 more source

Rational Design of Biosafety Level 2-Approved, Multidrug-Resistant Strains of Mycobacterium tuberculosis through Nutrient Auxotrophy

mBio, 2018
Multidrug-resistant (MDR) tuberculosis, defined as tuberculosis resistant to the two first-line drugs isoniazid and rifampin, poses a serious problem for global tuberculosis control strategies.
Catherine Vilchèze, Jacqueline Copeland, Tracy L. Keiser, Torin Weisbrod, Jacqueline Washington, Paras Jain, Adel Malek, Brian Weinrick, William R. Jacobs   +8 more
doaj   +1 more source

Genome-Based Metabolic Reconstruction Unravels the Key Role of B12 in Methionine Auxotrophy of an Ortho-Phenylphenol-Degrading Sphingomonas haloaromaticamans

Frontiers in Microbiology, 2020
Auxotrophy to amino acids and vitamins is a common feature in the bacterial world shaping microbial communities through cross-feeding relations. The amino acid auxotrophy of pollutant-degrading bacteria could hamper their bioremediation potential ...
Chiara Perruchon, Sotirios Vasileiadis, Evangelia S. Papadopoulou, Dimitrios G. Karpouzas   +3 more
doaj   +1 more source

Fructo-oligosaccharides and intestinal barrier function in a methionine–choline-deficient mouse model of nonalcoholic steatohepatitis

PLoS ONE, 2017
Impairments in intestinal barrier function, epithelial mucins, and tight junction proteins have been reported to be associated with nonalcoholic steatohepatitis. Prebiotic fructo-oligosaccharides restore balance in the gastrointestinal microbiome.
Kotaro Matsumoto, Mayuko Ichimura, K. Tsuneyama, Y. Moritoki, Hiromichi Tsunashima, K. Omagari, M. Hara, I. Yasuda, H. Miyakawa, K. Kikuchi   +9 more
semanticscholar   +1 more source

The Effect of Exogenous Protease in Broiler Diets on the Apparent Ileal Digestibility of Amino Acids and on Protease Activity in Jejunum

Acta Universitatis Agriculturae et Silviculturae Mendelianae Brunensis, 2016
The objective of this study was to evaluate the effect of a mono-component commercial serine protease supplement in broiler diets on apparent ileal amino acid digestibility and protease activity.
Vojtěch Rada, Martina Lichovníková, Marian Foltyn, Ivo Šafařík   +3 more
doaj   +1 more source

Docosahexaenoic acid (22:6 n-3)-rich microalgae along with methionine supplementation in broiler chickens: effects on production performance, breast muscle quality attributes, lipid profile, and incidence of white striping and myopathy

Poultry Science, 2021
The effect of docosahexaenoic acid (DHA, 22:6 n-3)-rich microalgae and methionine (Met) supplementation on production performance, incidence of breast muscle white striping (WS), and pathology, lipid profile, and meat quality aspects in broiler chickens ...
Ibrahim A. Khan, Nathan B. Parker, Christiane V. Löhr, Gita Cherian   +3 more
doaj  

Methionine deprivation suppresses triple-negative breast cancer metastasis in vitro and in vivo

OncoTarget, 2016
Nutrient deprivation strategies have been proposed as an adjuvant therapy for cancer cells due to their increased metabolic demand. We examined the specific inhibitory effects of amino acid deprivation on the metastatic phenotypes of the human triple ...
Hyein Jeon, Jae Hwan Kim, E. Lee, Y. Jang, J. Son, Jung Yeon Kwon, Tae-Gyu Lim, Sung-Han Kim, J. Park, Jong-Eun Kim, K. Lee   +10 more
semanticscholar   +1 more source

Methionine residues around phosphorylation sites are preferentially oxidized in vivo under stress conditions

Scientific Reports, 2017
Protein phosphorylation is one of the most prevalent and well-understood protein modifications. Oxidation of protein-bound methionine, which has been traditionally perceived as an inevitable damage derived from oxidative stress, is now emerging as ...
F. J. Veredas, Francisco R. Cantón, J. Aledo   +2 more
semanticscholar   +1 more source

Diagnostic and Prognostic Significance of Methionine Uptake and Methionine Positron Emission Tomography Imaging in Gliomas

Frontiers in Oncology, 2017
The present most common image diagnostic tracer in clinical practice for glioma is 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) for brain tumors diagnosis and prognosis.
Kamalakannan Palanichamy, Arnab Chakravarti   +1 more
doaj   +1 more source