Results 51 to 60 of about 501,506 (307)
Exposure to Toxic Heavy Metals Can Influence Homocysteine Metabolism?
Antioxidants, 2019 Background: Homocysteine is a sulfur amino acid whose metabolism is activated in two pathways: remethylation to methionine, which requires folate and vitamin B12, and transsulfuration to cystathionine, which needs pyridoxal-5’-phosphate.
Caterina Ledda +7 more
doaj +1 more source
Early Diagnosis of Classic Homocystinuria in Kuwait through Newborn Screening: A 6-Year Experience
International Journal of Neonatal Screening, 2021 Kuwait is a small Arabian Gulf country with a high rate of consanguinity and where a national newborn screening program was expanded in October 2014 to include a wide range of endocrine and metabolic disorders.
Hind Alsharhan +21 more
doaj +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
BiomoleculesCancer cells exhibit a well-documented, yet poorly understood, dependence on exogenous methionine, despite retaining the capacity to convert homocysteine to methionine.
Anna Andronicos +8 more
doaj +1 more source
Methionine synthesis in Neurospora. The isolation of cystathionine [PDF]
, 1947 Among artificially produced biochemical mutants of Neurospora, those which have lost the ability to synthesize methionine form the largest class. At the present writing 87 occurrences of the methionineless character have been observed in this laboratory ...
Horowitz, N. H.
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Recombinant methioninase (rMETase) is an effective therapeutic for BRAF-V600E-negative as well as -positive melanoma in patient-derived orthotopic xenograft (PDOX) mouse models. [PDF]
, 2017 Melanoma is a recalcitrant disease. Melanoma patients with the BRAF-V600E mutation have been treated with the drug vemurafenib (VEM) which targets this mutation.
Chmielowski, Bartosz +16 more
core +1 more source
Bacterial methionine biosynthesis
Microbiology, 2014 Methionine is essential in all organisms, as it is both a proteinogenic amino acid and a component of the cofactor,S-adenosyl methionine. The metabolic pathway for its biosynthesis has been extensively characterized inEscherichia coli; however, it is becoming apparent that most bacterial species do not use theE. colipathway.
Matteo P, Ferla, Wayne M, Patrick
openaire +2 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Effect of methionine and cysteine deprivation on growth of different natural isolates of Lactobacillus spp. in chemically defined media [PDF]
Archives of Biological Sciences, 2008 The purpose of this study was to determine the ability of natural isolates of lactobacilli from different ecological niches to grow in a chemically defined medium in the presence or absence of sulphur-containing amino acids, methionine and/or cysteine ...
Lozo Jelena +4 more
doaj +1 more source