Results 41 to 50 of about 364,567 (208)
Design of an Antifungal Methionine Inhibitor Not Antagonized by Methionine.
Biological and Pharmaceutical Bulletin, 1995 Only a few biosynthetic pathways in fungal cells have been used as antifungal targets. Therefore, the number of antifungals has been limited, and a cross-drug resistance among them has emerged in the therapy of mycoses. Under such circumstances, the identification of an antifungal with a new mode of action is highly desirable.
AOKI, Yuhko +5 more
openaire +3 more sources
Conformational dynamics, ligand binding and effects of mutations in NirE an S-adenosyl-L-methionine dependent Methyltransferase [PDF]
, 2016 Heme d1, a vital tetrapyrrol involved in the denitrification processes is synthesized from its precursor molecule precorrin-2 in a chemical reaction catalysed by an S-adenosyl-L-methionine (SAM) dependent Methyltransferase (NirE).
Singh, Warispreet +5 more
core +1 more source
Enzymatic Synthesis of L-Methionine Analogues and Application in a Methyltransferase Catalysed Alkylation Cascade [PDF]
, 2023 Chemical modification of small molecules is a key step for the development of pharmaceuticals. S-adenosyl-L-methionine (SAM) analogues are used by methyltransferases (MTs) to transfer alkyl, allyl and benzyl moieties chemo-, stereo- and regioselectively ...
Michael, Mohr +3 more
core +2 more sources
mBio, 2018 Multidrug-resistant (MDR) tuberculosis, defined as tuberculosis resistant to the two first-line drugs isoniazid and rifampin, poses a serious problem for global tuberculosis control strategies.
Catherine Vilchèze +8 more
doaj +1 more source
Natural Clays as Potential Amino Acids Carriers for Animal Nutrition Application
Applied Sciences, 2021 This study has the main purpose of testing natural carriers as more sustainable alternatives to polymeric coating. New clay-based hybrid organic–inorganic materials have been prepared.
Cinzia Cristiani +6 more
doaj +1 more source
, 2020 Methionine is a limiting amino acid (AA) in fish diets, particularly in those containing high levels of plant protein (PP), and is key in the immune system.
Colen, R. +5 more
core +1 more source
Fatty liver produced by dietary deficiencies: its pathogenesis and potentiation by ethanol
Journal of Lipid Research, 1969 In a study of the pathogenesis of hepatic fat accumulation under experimental conditions mimicking chronic alcoholism, rats were fed a low-fat diet, deficient in amino acids and choline, containing either ethanol or isocaloric amounts of carbohydrate ...
Charles S. Lieber +2 more
doaj +1 more source
Early Diagnosis of Classic Homocystinuria in Kuwait through Newborn Screening: A 6-Year Experience
International Journal of Neonatal Screening, 2021 Kuwait is a small Arabian Gulf country with a high rate of consanguinity and where a national newborn screening program was expanded in October 2014 to include a wide range of endocrine and metabolic disorders.
Hind Alsharhan +21 more
doaj +1 more source
Effect of methionine supplementation on methionine metabolism in growing cattle [PDF]
, 2002 Methionine is often the first limiting amino acid for growing cattle. This study was conducted to determine how methionine metabolism is regulated in the liver of growing steers.
Löest, C.A. +5 more
core +1 more source
BiomoleculesCancer cells exhibit a well-documented, yet poorly understood, dependence on exogenous methionine, despite retaining the capacity to convert homocysteine to methionine.
Anna Andronicos +8 more
doaj +1 more source