Results 191 to 200 of about 320,148 (311)

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Variable-Impulse Hammer Impact Test (VIHIT) Method for Improved Mode Shape Identification. [PDF]

Sensors (Basel)
Jensen A, Riley C.
europepmc   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source

An <i>ab initio</i> study and machine learning framework to capture the motional effects in solid-state NMR of lithium-ion conductors.

J Mater Chem A Mater
Zelin B, Poletayev AD, Davison E, Rees GJ, Payne BT, Bruce PG, Islam MS, Yates JR.   +7 more
europepmc   +1 more source

Validation of absolute dose calculation of a single 125I-seed for ophthalmic brachytherapy within distance range 1-15 mm using a diode detector. [PDF]

Acta Oncol
Rintala A, Reijonen V, Valve A, Tenhunen M.   +3 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

logLIRA: a method for reliable suppression of electrical stimulation artifacts enabling short-latency neural response recovery. [PDF]

J Neural Eng
Negri F, Guggenmos DJ, Barban F.
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Wireless Communication-Based Indoor Localization with Optical Initialization and Sensor Fusion. [PDF]

Sensors (Basel)
Leplawy M, Lipiński P, Morawska B, Korzeniewska E.   +3 more
europepmc   +1 more source

The induced 2-tuple linguistic generalized OWA operator and its application in linguistic decision making

We present the induced 2-tuple linguistic generalized ordered weighted averaging (2-TILGOWA) operator. This new aggregation operator extends previous approaches by using generalized means, order-inducing variables in the reordering of the arguments and ...
Jose M. Merigo Lindahl, Anna M. Gil-Lafuente   +1 more
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