Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
A penalized linear mixed model with generalized method of moments for prediction analysis on high-dimensional multi-omics data. [PDF]
Brief Bioinform, 2022 Wang X, Wen Y.
europepmc +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Joint Method of Moments (JMoM) and Successive Moment Cancellation (SMC) Multiuser Time Synchronization for ZP-OFDM-Based Waveforms Applicable to Joint Communication and Sensing. [PDF]
Sensors (Basel), 2023 Pourtahmasi Roshandeh K +2 more
europepmc +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Analysis of Faceted Gratings Using C-Method and Polynomial Expansion
PhotonicsThe coordinate-transformation-based differential method developed by Chandezon et al. is recognized as one of the simplest and most versatile approaches for modeling surface-relief gratings.
Gérard Granet, Kofi Edee
doaj +1 more source
Does political risk drive environmental degradation in BRICS countries? Evidence from method of moments quantile regression. [PDF]
Environ Sci Pollut Res Int, 2022 Adebayo TS +3 more
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Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
A Method of Moments Estimator of Tail Dependence in Elliptical Copula Models [PDF]
An elliptical copula model is a distribution function whose copula is that of an elliptical distri- bution. The tail dependence function in such a bivariate model has a parametric representation with two parameters: a tail parameter and a correlation ...
Krajina, A.
core
The environmental impact of governance: a system-generalized method of moments analysis. [PDF]
Environ Sci Pollut Res Int, 2021 Gök A, Sodhi N.
europepmc +1 more source