Results 61 to 70 of about 938,777 (344)

Editorial overview: Biophysical methods: behind the scenes of the cryo-EM revolution [PDF]

Current Opinion in Structural Biology, 2017
Editorial overview of "Biophysical methods: behind the scenes of the cryo-EM revolution , edited by Carol Robinson and Carla Schmidt" section, volume 46 of Current Opinion in Structural Biology.
Schmidt, C, Robinson, C
openaire   +2 more sources

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

STUDY OF A PROBLEM OF GRAPHIC ENGINEERING [PDF]

Fiabilitate şi Durabilitate, 2017
The paper proposes an approximate graphical method for determining the development of the revolution surface obtained by means of the deltoid. The approximate development of the revolution surfaces are based on general methods of development, provided ...
Liliana LUCA
doaj  

Computer program for predicting creep behavior of bodies of revolution [PDF]

, 1971
Computer program, CRAB, uses finite-element method to calculate creep behavior and predict steady-state stresses in an arbitrary body of revolution subjected to a time-dependent axisymmetric load.
Adams, R., Greenbaum, G.
core   +1 more source

Analysis of seismic stability of shells of revolution using probabilistic methods [PDF]

WIT Transactions on The Built Environment, 2011
This work presents numerical methods of calculation of earthquake resistance of shells of revolution based on the application of the theory of random processes combined with the FEM. Probabilistic character of seismic effect is determined by using artificial accelerograms based on stochastic process.
M. Danieli, J. Bloch, I. Halperin
openaire   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Five‐Year Disease Progression in Synuclein Seeding Positive Sporadic Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To provide a comprehensive description of disease progression in synuclein seeding assay (SAA) positive sporadic Parkinson Disease participants, using Neuronal Synuclein Disease integrated biological and functional impairment staging framework.
Paulina Gonzalez‐Latapi, Caroline Gochanour, Seung Ho Choi, Hyunkeun Cho, Chelsea Caspell‐Garcia, Christopher Coffey, Michael Brumm, David‐Erick Lafontant, Yuge Xiao, Thomas Tropea, John Seibyl, Caroline Tanner, Charles S. Venuto, Karl Kieburtz, Lana M. Chahine, Kathleen L. Poston, Andrew Siderowf, Kenneth Marek, Tanya Simuni, The Parkinson's Progression Markers Initiative   +19 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu, Xin Duan, Fatemeh Peymani, Jia Wang, Chengjia Bao, Chaolong Xu, Ying Zou, Zixuan Zhang, Yunxi Zhang, Tongyue Li, Martin Pavlov, Junling Wang, Minhan Song, Tianyu Song, Xiaodi Han, Mingxi Sun, Danmin Shen, Ruoyu Duan, Huafang Jiang, Manting Xu, Holger Prokisch, Fang Fang   +21 more
wiley   +1 more source

The Bases of Entrance and Role Making of Workers in the Islamic Revolution of Iran [PDF]

تحقیقات تاریخ اجتماعی, 2015
The Islamic revolution of Iran in 1357, due to its integrative nature, occurred as a result of interaction and cooperation among various communities and social classes.
Seyyed Hashem Aghajari, Morteza Veisi
doaj  

Application of the finite element method in the calculation of shells of revolution

Herald of the Azerbaijan Engineering Academy, 2022
The paper describes an algorithm for calculating structurally orthotropic shells of rotationwith an arbitrary shape of the meridian and an arbitrary law of change in the rigidity of the shellalong the meridian. In this case, a number of restrictions are imposed on the law of change in theshell stiffness.
A.N. Gurbanov, I.Z. Sardarova, L.A. Aliyeva   +2 more
openaire   +1 more source