Results 31 to 40 of about 2,532,405 (218)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Research Article Template

open access: yesJournal of Lithic Studies, 2005
MS Word template file for articles. This template can be used for the following types of articles. Research articles Research articles should present original research on completed projects or significant discoveries and must present clear ...
Otis Crandell
doaj   +1 more source

A scoping review to identify and describe the characteristics of theories, models and frameworks of health research partnerships

open access: yesHealth Research Policy and Systems, 2022
Background Engaging users of health research, namely knowledge users, as partners in the research process may to lead to evidence that is more relevant to the users.
B. J. Tittlemier   +4 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Evaluating pharmacist prescribing education programmes: a realist synthesis protocol

open access: yesBMJ Open
Introduction Pharmacist prescribing has evolved to meet healthcare system needs, but the effectiveness, mechanisms and contextual factors influencing education programmes remain poorly understood.
Charlotte E Rees   +4 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

POLITICS OF IDENTITY AND ITS CHALLENGES FOR DEMOCRATIC GOVERNANCE IN NIGERIA

open access: yesInternational Studies Journal, 2022
The study attempts to analyze the challenges identity politics pose to democratic governance and Nigeria's attempt at national development. The paper contends that a better understanding of the interplays militating against the country's quest for ...
Shuaib Olarewaju Moyosore
doaj  

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

A protocol to develop a Quality Assessment Tool for Realist Synthesis (QUATRES).

open access: yesPLoS ONE
A realist synthesis or review is a theory-driven, realist-informed interpretive approach to synthesizing secondary data, informing evidence-based practice, and explaining social phenomena.
Ferdinand C Mukumbang   +5 more
doaj   +1 more source

IDENTIFICATION OF THE IMPACT OF GLOBALIZATION ON THE DEVELOPMENT OF ACCOUNTING METHODOLOGY [PDF]

open access: yesBaltic Journal of Economic Studies, 2017
The relevance of the research consists in the significant lag behind the economies of post-Soviet countries from countries of the world, which play the role of driving forces of global economic globalization.
Tetiana Osadcha, Sergii Bardash
doaj   +1 more source

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