Results 101 to 110 of about 2,117,832 (174)

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Multi-modal radiomics features to predict overall survival of locally advanced esophageal cancer after definitive chemoradiotherapy. [PDF]

BMC Cancer
Yu N, Wan Y, Zuo L, Cao Y, Qu D, Liu W, Deng L, Zhang T, Wang W, Wang J, Lv J, Xiao Z, Feng Q, Zhou Z, Bi N, Niu T, Wang X.   +16 more
europepmc   +1 more source

Psychometric Properties of MyCog 2.0: A Human-Centered Cognitive Screening Tool for Older Adults. [PDF]

Int J Methods Psychiatr Res
Young SR, Shono Y, Hauner KK, Kim J, Dworak EM, Byrne GJ, Jones CM, Benavente JNY, Wolf MS, Nowinski CJ.   +9 more
europepmc   +1 more source

Comparison of Online Peer-Assisted Learning and Faculty-Led Teaching for Short Answer Questions. [PDF]

Clin Teach
Samra GS, Gaddu K, Hee JRWS, Brahmbhatt K, Bowrey D, Seabrook M.   +5 more
europepmc   +1 more source

Mercury poisoning in women and infants inhabiting the Gangetic plains of Bihar: risk assessment. [PDF]

BMC Public Health
Kumar A, Agarwal R, Kumar K, Chayal NK, Kumar G, Kumar R, Ali M, Srivastava A, Aryal S, Pandey T, Verma KS, Kumar D, Gajbhiye RL, Dhingra S, Pothuraju N, Peraman R, Bishwapriya A, Nandan R, Sharma A, Singh M, Ghosh AK.   +20 more
europepmc   +1 more source

Using Human-Centred Design to Codesign Patient Engagement Tools With a Patient Advisory Council: Successes and Challenges. [PDF]

Health Expect
Knaub M, Leon S, Pokharel S, Kiryanova V, Giroux K, Khanna P, Rychtera A, Duquette D, Mathura P, Verdin N, Ambasta A.   +10 more
europepmc   +1 more source

Enhanced dose prediction for head and neck cancer artificial intelligence‐driven radiotherapy based on transfer learning with limited training data

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Training deep learning dose prediction models for the latest cutting‐edge radiotherapy techniques, such as AI‐based nodal radiotherapy (AINRT) and Daily Adaptive AI‐based nodal radiotherapy (DA‐AINRT), is challenging due to limited data.
Hui‐Ju Wang, Austen Maniscalco, David Sher, Mu‐Han Lin, Steve Jiang, Dan Nguyen   +5 more
wiley   +1 more source