Results 101 to 110 of about 13,391,377 (337)

Hyodeoxycholic Acid Ameliorates Metabolic Syndrome Through Pathways of Primary Bile Acid Synthesis and Fatty Acid Degradation: Insights From a Rat Model

Drug Design, Development and Therapy
Meimei Chen,1,2,* Kaiyue Huang,1,2,* Wenqian Luo,1,2 Fei Zhang,1,2 Huijuan Gan,1,2 Zhaoyang Yang1– 3 1College of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, 350122, People’s Republic of
Chen M, Huang K, Luo W, Zhang F, Gan H, Yang Z   +5 more
doaj  

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Barriers to Early Breast Cancer Diagnosis in Sudanese Women Before the War

Breast Cancer: Targets and Therapy
Hana Eltayeb Salih Elamin,1 Hind Eltayeb Salih Elamin,2 Ghada Omer Hamad Abd El-Raheem,3 Mounkaila Noma1 1High Diploma in Research Methodology and Biostatistics, University of Medical Sciences and Technology UMST, Khartoum City, Khartoum State, Sudan ...
Elamin HES, Elamin HES, Abd El-Raheem GOH, Noma M   +3 more
doaj  

Methodological tools

, 2012
Methodological approaches for comparing metabolic theory predictions to empirical data fall into two general categories: 1) determining if the general functional form of a relationship predicted by the theory is valid; and 2) determining whether the observed values of the parameters match the specific quantitative predictions made by the theory.
White, Ethan P., Xiao, Xiao, Isaac, Nick J.B., Sibly, Richard M.   +3 more
openaire   +2 more sources

Optimal Data Split Methodology for Model Validation [PDF]

, 2011
The decision to incorporate cross-validation into validation processes of mathematical models raises an immediate question - how should one partition the data into calibration and validation sets?
Bryant, Corey, Miki, Kenji, Morrison, Rebecca, Prudhomme, Serge, Terejanu, Gabriel   +4 more
core  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

The impact of coffee on human health

Journal of Education, Health and Sport, 2019
Introduction: Coffee is one of the most popular beverages in the world. It contains lots of biologically active ingredients. These compounds not only have aromatic properties, but many of them also have antioxidant, hepatoprotective, anti-inflammatory ...
Aleksandra Chałupnik, Aleksandra Borkowska, Anna Sobstyl, Zuzanna Chilimoniuk, Maciej Dobosz, Paulina Sobolewska, Halina Piecewicz-Szczęsna   +6 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Selected Reliable Indicators of Sustainable Land Management (SLM) in the European Union

Visegrad Journal on Bioeconomy and Sustainable Development, 2017
The concept of sustainability and the feasibility options have been discussed in specialized literature sources for about three decades only. Sustainable development has several definitions; it is defined both in narrow and wider sense. The definition of
Tóth-Naár Zsuzsanna, Naár Tamás Antal, Sőreg Ádám Pál, Vinogradov Sergey   +3 more
doaj   +1 more source