Results 51 to 60 of about 9,839,628 (354)

From quality to outcomes: a national study of afterschool STEM programming

open access: yesInternational Journal of STEM Education, 2019
Background State afterschool networks across the US are engaged in system-building efforts to improve the quality of science, technology, engineering, and math (STEM)-focused afterschool programming.
Patricia J. Allen   +6 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

The correlation between measles vaccination rate of children in Poland and incidence rate of this disease from 1998 to 2017 and in Italy from 2012 to 2017

open access: yesJournal of Education, Health and Sport, 2018
Introduction. Measles is a highly contagious disease capable of inducing epidemics, which strike every 2 to 3 years. Before implementing the vaccine in 1963 measles was devastating communities leading to 135 million of victims and 6 million died because ...
Dorota Sokół   +5 more
doaj   +3 more sources

The Smooth Away From Expected (SAFE) non-inferiority frontier: theory and implementation with an application to the D3 trial

open access: yesTrials, 2023
Background In a non-inferiority trial, the choice of margin depends on the expected control event risk. If the true risk differs from expected, power and interpretability of results can be affected. A non-inferiority frontier pre-specifies an appropriate
Matteo Quartagno   +4 more
doaj   +1 more source

Quantifying Bar Strength: Morphology Meets Methodology

open access: yes, 2004
A set of objective bar-classification methods have been applied to the Ohio State Bright Spiral Galaxy Survey (Eskridge et al. 2002). Bivariate comparisons between methods show that all methods agree in a statistical sense.
BG Elmegreen   +9 more
core   +2 more sources

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

Microservices Validation: Methodology and Implementation [PDF]

open access: yes, 2015
Due to the wide spread of cloud computing, arises actual question about architecture, design and implementation of cloud applications. The microservice model describes the design and development of loosely coupled cloud applications when computing ...
Radchenko, G., Savchenko, D.
core  

Coding Theory: the unit-derived methodology

open access: yes, 2018
The unit-derived method in coding theory is shown to be a unique optimal scheme for constructing and analysing codes. In many cases efficient and practical decoding methods are produced.
Hurley, Donny, Hurley, Ted
core   +1 more source

CCT4 promotes tunneling nanotube formation

open access: yesFEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto   +3 more
wiley   +1 more source

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