Results 71 to 80 of about 9,808,147 (301)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Range of Body Mass Index and the risk of breast cancer

Journal of Education, Health and Sport, 2018
Introduction. Obesity leads to an increased incidence of many diseases. The research subject of scientists is the impact of obesity on breast cancer as one of the most commonly diagnosed cancers among women. Aim of the study.
Alicja Sobek, Karol Lorenc, Urszula Fałkowska, Julita Poleszak, Halina Piecewicz-Szczęsna   +4 more
doaj   +3 more sources

Tracing ChatGPT Use in Spain: Differences Among Population Groups in Adoption and Engagement

Human Behavior and Emerging Technologies
Artificial intelligence (AI) tools are transforming how people work, learn and create, reshaping everyday digital interactions. Among them, ChatGPT stands out as a particularly disruptive innovation, reaching 100 million users within two months of its ...
Carlos Ochoa, Lucía Fernández Melero, Melanie Revilla   +2 more
doaj   +1 more source

Methodology for quantum logic gate constructions

, 2000
We present a general method to construct fault-tolerant quantum logic gates with a simple primitive, which is an analog of quantum teleportation. The technique extends previous results based on traditional quantum teleportation (Gottesman and Chuang ...
A. Kitaev, A. M. Steane, A. R. Calderbank, A. Steane, C. H. Bennett, D. Gottesman, D. Gottesman, D. Gottesman, Debbie W. Leung, E. Knill, G. Brassard, Isaac L. Chuang, J. L. Hennessey, J. Preskill, M. A. Nielsen, P. O. Boykin, P. Shor, P. Shor, R. Cleve, Xinlan Zhou   +19 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Hyodeoxycholic Acid Ameliorates Metabolic Syndrome Through Pathways of Primary Bile Acid Synthesis and Fatty Acid Degradation: Insights From a Rat Model

Drug Design, Development and Therapy
Meimei Chen,1,2,* Kaiyue Huang,1,2,* Wenqian Luo,1,2 Fei Zhang,1,2 Huijuan Gan,1,2 Zhaoyang Yang1– 3 1College of Traditional Chinese Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian, 350122, People’s Republic of
Chen M, Huang K, Luo W, Zhang F, Gan H, Yang Z   +5 more
doaj  

Pade Interpolation: Methodology and Application to Quarkonium

, 2000
A novel application of the Pade approximation is proposed in which the Pade approximant is used as an interpolation for the small and large coupling behaviors of a physical system, resulting in a prediction of the behavior of the system at intermediate ...
Leung, C. N., Murakowski, J. A.
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methodology for comparing design processes [PDF]

, 2003
Engineering Design Centre, University of Cambridge; Design and Innovation, Open UniversityWe gain insights into design processes by recognising similarities to other processes, often in radically different industries.
,, Earl, CF, Eckert, CM, O'Donovan, BD, Stacey, MK   +4 more
core   +1 more source