Results 251 to 260 of about 3,716,507 (339)

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Reversible excision of the wzy locus in Salmonella Typhimurium may aid recovery following phage predation. [PDF]

PLoS Genet
Charity OJ, Thilliez G, Al-Khanaq H, Acton L, Kolenda R, Bawn M, Petrovska L, Kingsley RA.   +7 more
europepmc   +1 more source

Soman induces endoplasmic reticulum stress and apoptosis of cerebral organoids via the GRP78‐ATF6‐CHOP signaling pathway

FEBS Open Bio, EarlyView.
Cerebral organoids were employed as a novel model to explore the neurotoxicity of soman. Soman inhibited acetylcholinesterase activity, increased cell apoptosis and upregulated endoplasmic reticulum (ER) stress markers glucose‐regulated protein 78 (GRP78), activating transcription factor 6 (ATF6) and C/EBP homologous protein (CHOP).
Yue Wei, Zhanbiao Liu, Jingjing Shi, Qian Jin, Wenqian Chen, Xuejun Chen, Liqin Li, Hui Chen   +7 more
wiley   +1 more source

Brinkmanship in intragenomic conflict. [PDF]

Proc Biol Sci
Kennedy P, Higginson AD.
europepmc   +1 more source

Advanced glycation end products promote the release of endothelial cell‐derived mitocytosis

FEBS Open Bio, EarlyView.
Under diabetic conditions, AGEs induce mitochondrial damage in HUVECs, activating migrasome‐mediated mitocytosis. Migrasomes encapsulate damaged mitochondria and are released into the extracellular space, facilitating intercellular mitochondrial transfer.
Rong Liu, Yuhao Zhang, Tiantian Ge, Hao Wu, Yongbin Ma, Honghua Ye, Fei Guo   +6 more
wiley   +1 more source

Application of allogeneic adult mesenchymal stem cells in the treatment of venous ulcers: A phase I/II randomized controlled trial protocol. [PDF]

PLoS One
Costela-Ruiz VJ, González-Vigil E, Espinosa-Ibáñez O, Alcázar-Caballero RM, Melguizo-Rodríguez L, Fernández-López O, Arias-Santiago S.   +6 more
europepmc   +1 more source

Co‐expression of HSV‐1 ICP34.5 enhances the expression of gene delivered by self‐amplifying RNA and mitigates its immunogenicity

FEBS Open Bio, EarlyView.
ICP34.5 is one of the most important antihost response proteins. The saRNA‐encoding HSV‐1 neurovirulence protein ICP34.5 clearly mediated the eukaryotic initiation factor 2 alpha subunit (eIF2α) dephosphorylation and significant suppression of innate immune responses in vitro, leading to enhanced expression of the saRNA‐encoded gene.
Xuemin Lu, Yabin Wu, Chunye Zhao, Jie Zheng, Shangwu Chen, Yigang Wang, Yulong Xia   +6 more
wiley   +1 more source

Potential Association of the <i>CSMD1</i> Gene with Moderate Intellectual Disability, Anxiety Disorder, and Obsessive-Compulsive Personality Traits. [PDF]

Int J Mol Sci
Musumeci A, Vinci M, Treccarichi S, Greco D, Rizzo B, Gloria A, Federico C, Saccone S, Musumeci SA, Calì F.   +9 more
europepmc   +1 more source

An open chat with…Pierre Santucci: a testimonial on why we should engage with scientific societies and their journals

FEBS Open Bio, EarlyView.
Pierre SANTUCCI is a principal investigator at the CNRS—Aix Marseille Université and recipient of a FEBS Excellence Award. He was also recently appointed FEBS Open Bio Publishing Liaison Officer. In this Open Chat with…, he discusses the importance of engaging with scientific societies and their journals, and highlights through some of his personal ...
Pierre Santucci, Ioannis Tsagakis
wiley   +1 more source

Microplastic Pollution and Its Ecological Risks in the Xisha Islands, South China Sea. [PDF]

Toxics
Wei W, Zhang Y, Wang L, Xing Q, Xiang J, Zhang Y, Peng Q, Chen Y, Hu Y, Ma Y, Mo L.   +10 more
europepmc   +1 more source