Results 51 to 60 of about 3,630,829 (295)

Case studies: understanding players and the contexts in which they play. Workshop on Crossing Domains: Diverse Perspectives on Players [PDF]

, 2015
Over recent years, the study of games and players has become an established domain with HCI research. However, while a range of methods has been employed within this area, questions remain as to how to develop in-depth understandings of players and the ...
Cox, Anna, Iacovides, Ioanna
core  

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Understanding and optimising patient and public involvement in trial oversight: an ethnographic study of eight clinical trials

Trials, 2020
Background Trial oversight is important for trial governance and conduct. Patients and/or lay members of the public are increasingly included in trial oversight committees, influenced by international patient and public involvement (PPI) initiatives to ...
K. D. Coulman, A. Nicholson, A. Shaw, A. Daykin, L. E. Selman, R. Macefield, G. W. Shorter, H. Cramer, M. R. Sydes, C. Gamble, M. E. Pick, G. Taylor, J. A. Lane   +12 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Evaluating the construct validity of text embeddings with application to survey questions

EPJ Data Science, 2022
Text embedding models from Natural Language Processing can map text data (e.g. words, sentences, documents) to meaningful numerical representations (a.k.a. text embeddings).
Qixiang Fang, Dong Nguyen, Daniel L. Oberski   +2 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

RT4Win: A Windows-Based Program for Randomization Tests

Psychologica Belgica, 2012
A randomization test (RndT) is a statistical significance test for which the validity is based on the random assignment of experimental units in a designed experiment. In a random sampling setting, it can also be applied in a very general way because its
Ming Huo, Patrick Onghena
doaj   +1 more source

Performance of active learning models for screening prioritization in systematic reviews: a simulation study into the Average Time to Discover relevant records

Systematic Reviews, 2023
Background Conducting a systematic review demands a significant amount of effort in screening titles and abstracts. To accelerate this process, various tools that utilize active learning have been proposed. These tools allow the reviewer to interact with
Gerbrich Ferdinands, Raoul Schram, Jonathan de Bruin, Ayoub Bagheri, Daniel L. Oberski, Lars Tummers, Jelle Jasper Teijema, Rens van de Schoot   +7 more
doaj   +1 more source

Gravitational Lensing & Stellar Dynamics [PDF]

, 2005
Strong gravitational lensing and stellar dynamics provide two complementary and orthogonal constraints on the density profiles of galaxies. Based on spherically symmetric, scale-free, mass models, it is shown that the combination of both techniques is ...
Combes, F, Deffayet, C, Fort, B, Koopmans, L. V. E., Mamon, GA   +4 more
core   +1 more source