Results 61 to 70 of about 1,465,762 (307)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

RT4Win: A Windows-Based Program for Randomization Tests

open access: yesPsychologica Belgica, 2012
A randomization test (RndT) is a statistical significance test for which the validity is based on the random assignment of experimental units in a designed experiment. In a random sampling setting, it can also be applied in a very general way because its
Ming Huo, Patrick Onghena
doaj   +1 more source

Performance of active learning models for screening prioritization in systematic reviews: a simulation study into the Average Time to Discover relevant records

open access: yesSystematic Reviews, 2023
Background Conducting a systematic review demands a significant amount of effort in screening titles and abstracts. To accelerate this process, various tools that utilize active learning have been proposed. These tools allow the reviewer to interact with
Gerbrich Ferdinands   +7 more
doaj   +1 more source

Science, Technology and Society: A Methodological Perspective [PDF]

open access: yesInternational Journal of Technology and Design Education, 1997
Methodology offers a perspective on technology that differs from a historical or sociological one. It focuses on the scientific, technological and social factors that are to be taken into account in technological developments. Other approaches tend to focus on actors rather than factors.
openaire   +1 more source

Journal of Methodology of Social Sciences and Humanities; No. 103

open access: yes
Study of the relationship between philosophy, philosophy of social sciences and humanities, methodology and research method; The role of philosophy and methodology of social sciences and humanities in the quantitative and qualitative improvement of ...
Methodology of Social Sciences and Humanities, J (via Mendeley Data)
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Data Science Methodology for Cybersecurity Projects

open access: yesComputer Science & Information Technology, 2018
Cybersecurity solutions are traditionally static and signature-based. The traditional solutions along with the use of analytic models, machine learning and big data could be improved by automatically trigger mitigation or provide relevant awareness to control or limit consequences of threats. This kind of intelligent solutions is covered in the context
Farhad Foroughi, Peter Luksch
openaire   +3 more sources

Journal of Methodology of Social Sciences and Humanities; No. 104

open access: yes
Study of the relationship between philosophy, philosophy of social sciences and humanities, methodology and research method; The role of philosophy and methodology of social sciences and humanities in the quantitative and qualitative improvement of ...
Methodology of Social Sciences and Humanities, J (via Mendeley Data)
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Journal of Methodology of Social Sciences and Humanities; No.96

open access: yes
Study of the relationship between philosophy, philosophy of social sciences and humanities, methodology and research method; The role of philosophy and methodology of social sciences and humanities in the quantitative and qualitative improvement of ...
Methodology of Social Sciences and Humanities, J (via Mendeley Data)
core   +1 more source

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