Results 151 to 160 of about 1,983,043 (219)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Machine Learning-Driven Refinement of Reactive Force Fields via Hierarchical "Center-Environment" Features for Energetic Molecular Crystals. [PDF]

Molecules
He Q, Wang P, He X, Zhang J, Liu Y.
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Changing Etiological Patterns of Pediatric Meningitis: A Three-Year Experience from a Tertiary Pediatric Emergency Hospital in Romania. [PDF]

Medicina (Kaunas)
Vulcanescu DD, Horhat FG, Ciortuz C, Varga NI, Bagiu IC.   +4 more
europepmc   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Illustrative Variant-Positive Molecular Autopsy Series: Autopsy-Led Concordance of Loeys-Dietz Spectrum Findings in Eight Florida Sudden Deaths. [PDF]

Genes (Basel)
Fernández-Cadena J, Naylor EW, Bhattacharjee A.   +2 more
europepmc   +1 more source

Portable qPCR and ddPCR Diagnostics for Cercospora Leaf Spot: Integrating Field and Laboratory Detection of <i>Cercospora beticola</i> in Beet. [PDF]

J Fungi (Basel)
Crudele M, Bati MD, Laera S, Laguardia C, Mascia T, Faretra F, De Miccolis Angelini RM.   +6 more
europepmc   +1 more source

Medicine's 'Basic' Mistake: How the Molecular Revolution Displaced an Entire Category of Inquiry. [PDF]

J Eval Clin Pract
Horwitz RI, Concato J.
europepmc   +1 more source