Results 151 to 160 of about 1,906,800 (219)

Bridging the diagnostic gap: the role of culture methods in the era of syndromic panels for central nervous system infections. [PDF]

Front Cell Infect Microbiol
Sberna G, D'Arezzo S, Valli MB, Nisii C, Lalle E, Selleri M, Brillo F, Palazzo CG, Venditti C, Rotondo C, Antonelli V, Maggi F, Fontana C, INMI Laboratories Group .   +13 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Molecular detection and phylogenetic characterization of Babesia and Ehrlichia in free-living opossums from southeastern Brazil. [PDF]

Acta Parasitol
Ribeiro SR, Rodrigues LP, Mochiuti JO, Resende CEV, Gazeta GS, Borsoi AB, da Cruz MGC, Bitencourth K, Teixeira RHF, da Lima LSS.   +9 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Beyond pathogen-specific preparedness: adaptable laboratory systems for emerging infections. [PDF]

Lancet Reg Health Eur
Sánchez-Seco MP, Palacios G.
europepmc   +1 more source

MolPIF: a parameter interpolation flow model for molecule generation. [PDF]

Bioinformatics
Jin Y, Wang J, Tang Y, Xiang W, Cao D, Teng D, Fan Z, Xiong J, Sheng X, Zeng C, An D, Zheng M, Zheng S, Shi Q.   +13 more
europepmc   +1 more source

CEDR: robust consensus cancer subtyping with multi-omics data via ensemble dimensionality reduction. [PDF]

Brief Bioinform
Cao H, Xu Z, Lin S, Du G, Wang T, Wang J, Yang X, Fang R, Luo Y, Zeng P, Yu H, Zhang Y, Cui Y.   +12 more
europepmc   +1 more source