Results 91 to 100 of about 63,025,606 (387)

Promoting awareness of key resources for evidence-informed decision making in public health: An evaluation of a webinar series about knowledge translation methods and tools

Frontiers in Public Health, 2016
The National Collaborating Centre for Methods and Tools (NCCMT) has developed several resources to support evidence-informed decision making – the process of distilling and disseminating best available evidence from research, context and experience – and
Jennifer eYost, Jeannie eMackintosh, Kristin eRead, Maureen eDobbins   +3 more
doaj   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

SpiderPhy dataset: A multimodal dataset of Physiological, Psychometric and Behavioral Responses to fear stimuli

Scientific Data
The SpiderPhy dataset is a dataset of physiological, psychometric, and behavioral data from subclinical spider fearful individuals (N = 54) who underwent exposure to spider stimuli.
Cindy S. Lor, David Steyrl, Alexander Karner, Sebastian J. Götzendorfer, Anne Klimesch, Stephanie J. Eder, Fabian M. Renz, Johannes Rother, Frank Scharnowski, Filip Melinscak   +9 more
doaj   +1 more source

Using patient values and preferences to inform the importance of health outcomes in practice guideline development following the GRADE approach

Health and Quality of Life Outcomes, 2017
Background There are diverse opinions and confusion about defining and including patient values and preferences (i.e. the importance people place on the health outcomes) in the guideline development processes.
Yuan Zhang, Pablo Alonso Coello, Jan Brożek, Wojtek Wiercioch, Itziar Etxeandia-Ikobaltzeta, Elie A. Akl, Joerg J. Meerpohl, Waleed Alhazzani, Alonso Carrasco-Labra, Rebecca L. Morgan, Reem A. Mustafa, John J. Riva, Ainsley Moore, Juan José Yepes-Nuñez, Carlos Cuello-Garcia, Zulfa AlRayees, Veena Manja, Maicon Falavigna, Ignacio Neumann, Romina Brignardello-Petersen, Nancy Santesso, Bram Rochwerg, Andrea Darzi, Maria Ximena Rojas, Yaser Adi, Claudia Bollig, Reem Waziry, Holger J. Schünemann   +27 more
doaj   +1 more source

A register-based census: what is the potential for New Zealand? [PDF]

Some countries, including Finland and Denmark, are now conducting their population censuses using administrative data registers rather than a nationwide survey of households.
Christine Bycroft
core  

Methods of Hierarchical Clustering [PDF]

, 2011
We survey agglomerative hierarchical clustering algorithms and discuss efficient implementations that are available in R and other software environments. We look at hierarchical self-organizing maps, and mixture models.
Contreras, Pedro, Murtagh, Fionn
core   +2 more sources

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Retracted: Antitumor Molecular Mechanism of Chlorogenic Acid on Inducting Genes GSK-3β and APC and Inhibiting Gene β-Catenin

Journal of Analytical Methods in Chemistry, 2021
Journal of Analytical Methods in Chemistry
doaj   +1 more source

Features of databases that supported searching for rapid evidence synthesis during COVID-19: implications for future public health emergencies

BMC Medical Research Methodology
Background As evidence related to the COVID-19 pandemic surged, databases, platforms, and repositories evolved with features and functions to assist users in promptly finding the most relevant evidence. In response, research synthesis teams adopted novel
Leah Hagerman, Emily C. Clark, Sarah E. Neil-Sztramko, Taylor Colangeli, Maureen Dobbins   +4 more
doaj   +1 more source

Graph Neural Networks: A Review of Methods and Applications [PDF]

AI Open, 2018
Jie Zhou, Ganqu Cui, Zhengyan Zhang, Cheng Yang, Zhiyuan Liu, Maosong Sun   +5 more
semanticscholar   +1 more source