Results 111 to 120 of about 32,039,160 (298)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Retracted: The Studies of Chlorogenic Acid Antitumor Mechanism by Gene Chip Detection: The Immune Pathway Gene Expression

Journal of Analytical Methods in Chemistry, 2020
Journal of Analytical Methods in Chemistry
doaj   +1 more source

Learning on the job: using Artificial Intelligence to support rapid review methods

Journal of the Medical Library Association
The National Collaborating Centre for Methods and Tools’ (NCCMT) Rapid Evidence Service conducts rapid reviews on priority questions to respond to the needs of public health decision-makers.
Kristin Rogers, Leah Hagerman, Sarah Neil-Sztramko, Maureen Dobbins   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Common statistical errors in systematic reviews: A tutorial

Cochrane Evidence Synthesis and Methods
The aim of this article is to present the most common statistical errors in meta‐analyses included in systematic reviews; these are confusing standard deviation and standard error, using heterogeneity estimators for choosing between a common‐effect and ...
Afroditi Kanellopoulou, Kerry Dwan, Rachel Richardson   +2 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Alcohol consumption as a socially contagious phenomenon in the Framingham Heart Study social network

Scientific Reports
We use longitudinal social network data from the Framingham Heart Study to examine the extent to which alcohol consumption is influenced by the network structure.
Maarten W. J. van den Ende, Han L. J. van der Maas, Sacha Epskamp, Mike H. Lees   +3 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

SUSTAINABILITY ASPECTS OF PROGRESSIVE CAVITY PUMPS USED IN OIL PRODUCTION [PDF]

Fiabilitate şi Durabilitate, 2013
Pump, sucker rod and tubing string wear is directly proportional to the number of revolutions,therefore the use of larger displacement pumps operated at lower speeds can significantly extend equipmentlife.
Marius STAN
doaj