Results 221 to 230 of about 24,427,288 (283)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Roadmap for inferring metabolic regulation using multiomics, machine learning, and genome-scale modeling. [PDF]

NPJ Metab Health Dis
Schildcrout R, Rhoads N, Chandrasekaran S.   +2 more
europepmc   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Evaluation of replication success: A statistical perspective and extended analysis of the SCORE data. [PDF]

PLoS One
van Aert RCM, van Assen MALM, López-Nicolás R.   +2 more
europepmc   +1 more source

Assessing EHR Cohort Fitness With Partially Paired Registry Data: A New Statistical Approach Applied to Maternal Health in OneFlorida. [PDF]

Clin Transl Sci
Harrall KK, Muller KE, Louis-Jacques AF, Barrow SB, Li Q, Shenkman EA.   +5 more
europepmc   +1 more source

Ability of clinical assessment methods to differentiate levels of competence in undergraduate nursing education: a scoping review protocol. [PDF]

BMJ Open
AlMekkawi M, Al Maqbali M, Al Sheryani R, ElKhalil R.   +3 more
europepmc   +1 more source