Results 31 to 40 of about 63,025,606 (387)

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Approaches to interpreting and choosing the best treatments in network meta-analyses

Systematic Reviews, 2017
When randomized trials have addressed multiple interventions for the same health problem, network meta-analyses (NMAs) permit researchers to statistically pool data from individual studies including evidence from both direct and indirect comparisons ...
L. Mbuagbaw, B. Rochwerg, R. Jaeschke, D. Heels-Andsell, W. Alhazzani, L. Thabane, Gordon H. Guyatt   +6 more
doaj   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

The future is in childhood: Evaluation of the quality of sustainability programmes in the early years

SHS Web of Conferences, 2016
During the last decade Environmental Education (EE) programs have drawn attraction from both experts and educators as a way to answer the increasing preoccupation about the different challenges and problems faced by the Environment. For this reason, many
López-Alcarria Abigail, Gutiérrez-Pérez José, Rodríguez-Sabiote Clemente, Poza-Vilches Fátima   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Preprocessing Approach for Power Transformer Maintenance Data Mining Based on k-Nearest Neighbor Completion and Principal Component Analysis

International Transactions on Electrical Energy Systems, 2022
The accuracy of a knowledge extraction algorithm in a large database depends on the quality of the data preprocessing and the methods used. The massive amounts of data that we collect every day are putting storage capacity at a premium.
Moïse Manyol, Samuel Eke, Alphonse J. M. Massoma, Alain Biboum, Ruben Mouangue   +4 more
doaj   +1 more source

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Method Pluralism, Method Mismatch & Method Bias

, 2019
Pluralism about scientific method is more-or-less accepted, but the consequences have yet to be drawn out. Scientists adopt different methods in response to different epistemic situations: depending on the system they are interested in, the resources at their disposal, and so forth.
Currie, AM, Avin, S
openaire   +2 more sources

Pricing Methods [PDF]

, 1992
In order to consider the range of pricing methods available, it is first necessary to choose a definition for road pricing. The term "road pricing" has been criticised as an inaccurate description of systems which is applied to (Thompson, 1990) and ...
Milne, D.
core