Results 41 to 50 of about 43,024,139 (304)

Non-invasive methods to assess muscle function in dogs: A scoping review

Frontiers in Veterinary Science, 2023
Skeletal muscle function can be affected by multiple disorders in dogs of which cranial cruciate ligament rupture or disease (CCLD) is one of the most common.
Kathrine Højte Dahl, Mette Kreutzfeldt Zebis, Mette Kreutzfeldt Zebis, Anne Désiré Vitger, James Edward Miles, Tine Alkjær, Tine Alkjær   +6 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Kernel methods

, 2023
This chapter introduces a powerful class of machine learning approaches called kernel methods, which present an alternative to arguably more widely known neural network approaches. Kernel methods can learn even highly nonlinear problems by making an implicit transformation from a low-dimensional input space into a higher-dimensional feature space. This
Pinheiro Jr, Max, Dral, Pavlo
openaire   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Unveiling the social fabric through a temporal, nation-scale social network and its characteristics

Scientific Reports
Social networks shape individuals’ lives, influencing everything from career paths to health. This paper presents a registry-based, multi-layer and temporal network of the entire Danish population from 2008 to 2021.
Jolien Cremers, Benjamin Kohler, Benjamin Frank Maier, Stine Nymann Eriksen, Johanna Einsiedler, Frederik Kølby Christensen, Sune Lehmann, David Dreyer Lassen, Laust Hvas Mortensen, Andreas Bjerre-Nielsen   +9 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Application of the target trial emulation framework to external comparator studies

Frontiers in Drug Safety and Regulation
External comparator (EC) studies are increasingly being used to generate evidence that supports the evaluation of emerging pharmacological treatments for regulatory and health technology assessment (HTA) purposes.
Kellyn Arnold, Luis Antunes, Briana Coles, Hopin Lee   +3 more
doaj   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

CFD Simulation of an Industrial Dust Cyclone Separator: A Comparison with Empirical Models: The Influence of the Inlet Velocity and the Particle Size on Performance Factors in Situation of High Concentration of Particles

Journal of Engineering
The present work is dedicated to the study of multiphase turbulent and three-dimensional rotational flow in dust cyclones, a contribution to air pollution control.
Tchinda Vermande Paganel, Epee Fabrice Alban, Mezoue Adiang Cyrille, Claude Valery Ngayihi Abbe   +3 more
doaj   +1 more source

Towards a Deep Automatic Generation of Figure-ground Maps [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Figure-ground maps play a key role in many disciplines where urban planning or analysis is involved. In this context, the automatic generation of such maps with respect to certain requirements and constraints is an important task.
L. Arzoumanidis, J. Hecht, Y. Dehbi
doaj   +1 more source