Results 51 to 60 of about 33,945,293 (343)

ERBIN limits epithelial cell plasticity via suppression of TGF‐β signaling

FEBS Letters, EarlyView.
In breast and lung cancer patients, low ERBIN expression correlates with poor clinical outcomes. Here, we show that ERBIN inhibits TGF‐β‐induced epithelial‐to‐mesenchymal transition in NMuMG breast and A549 lung adenocarcinoma cell lines. ERBIN suppresses TGF‐β/SMAD signaling and reduces TGF‐β‐induced ERK phosphorylation.
Chao Li, Gerard van der Zon, Peter ten Dijke, Tong Shen   +3 more
wiley   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Towards a Deep Automatic Generation of Figure-ground Maps [PDF]

ISPRS Annals of the Photogrammetry, Remote Sensing and Spatial Information Sciences
Figure-ground maps play a key role in many disciplines where urban planning or analysis is involved. In this context, the automatic generation of such maps with respect to certain requirements and constraints is an important task.
L. Arzoumanidis, J. Hecht, Y. Dehbi
doaj   +1 more source

Material and methods [PDF]

, 2006
This chapter introduces the cases and the disciplinary approaches and methods. The BERAS study had a case study approach, and this report presents the interdisciplinary synthesis of the multidisciplinary study.
Granstedt, Artur, Kahiluoto, Helena, Kakriainen, Salla, Sumelius, John   +3 more
core  

C‐mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells

FEBS Letters, EarlyView.
C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi, Takehiro Suzuki, Ryota Kawahara, Natsumi Harai, Naoshi Dohmae, Siro Simizu   +5 more
wiley   +1 more source

Unveiling the social fabric through a temporal, nation-scale social network and its characteristics

Scientific Reports
Social networks shape individuals’ lives, influencing everything from career paths to health. This paper presents a registry-based, multi-layer and temporal network of the entire Danish population from 2008 to 2021.
Jolien Cremers, Benjamin Kohler, Benjamin Frank Maier, Stine Nymann Eriksen, Johanna Einsiedler, Frederik Kølby Christensen, Sune Lehmann, David Dreyer Lassen, Laust Hvas Mortensen, Andreas Bjerre-Nielsen   +9 more
doaj   +1 more source

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

FEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

CFD Simulation of an Industrial Dust Cyclone Separator: A Comparison with Empirical Models: The Influence of the Inlet Velocity and the Particle Size on Performance Factors in Situation of High Concentration of Particles

Journal of Engineering
The present work is dedicated to the study of multiphase turbulent and three-dimensional rotational flow in dust cyclones, a contribution to air pollution control.
Tchinda Vermande Paganel, Epee Fabrice Alban, Mezoue Adiang Cyrille, Claude Valery Ngayihi Abbe   +3 more
doaj   +1 more source

Application of the target trial emulation framework to external comparator studies

Frontiers in Drug Safety and Regulation
External comparator (EC) studies are increasingly being used to generate evidence that supports the evaluation of emerging pharmacological treatments for regulatory and health technology assessment (HTA) purposes.
Kellyn Arnold, Luis Antunes, Briana Coles, Hopin Lee   +3 more
doaj   +1 more source