Results 51 to 60 of about 14,063,414 (314)

SpiDa-MRI: behavioral and (f)MRI data of adults with fear of spiders

Scientific Data
Neuroimaging has greatly improved our understanding of phobic mechanisms. To expand on these advancements, we present data on the heterogeneity of neural patterns in spider phobia combined with various psychological dimensions of spider phobia, using ...
Mengfan Zhang, Alexander Karner, Kathrin Kostorz, Sophia Shea, David Steyrl, Filip Melinscak, Ronald Sladky, Cindy Sumaly Lor, Frank Scharnowski   +8 more
doaj   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Using patient values and preferences to inform the importance of health outcomes in practice guideline development following the GRADE approach

Health and Quality of Life Outcomes, 2017
Background There are diverse opinions and confusion about defining and including patient values and preferences (i.e. the importance people place on the health outcomes) in the guideline development processes.
Yuan Zhang, Pablo Alonso Coello, Jan Brożek, Wojtek Wiercioch, Itziar Etxeandia-Ikobaltzeta, Elie A. Akl, Joerg J. Meerpohl, Waleed Alhazzani, Alonso Carrasco-Labra, Rebecca L. Morgan, Reem A. Mustafa, John J. Riva, Ainsley Moore, Juan José Yepes-Nuñez, Carlos Cuello-Garcia, Zulfa AlRayees, Veena Manja, Maicon Falavigna, Ignacio Neumann, Romina Brignardello-Petersen, Nancy Santesso, Bram Rochwerg, Andrea Darzi, Maria Ximena Rojas, Yaser Adi, Claudia Bollig, Reem Waziry, Holger J. Schünemann   +27 more
doaj   +1 more source

Unified Behavioral Scoring for Preclinical Models

Frontiers in Neuroscience, 2020
Preclinical mental health research relies upon animal models, and whilst many encouraging advances are being made, reproducibility and translational relevance may be limited by sub-optimal testing or model choices.
David J. Harrison, Hugo D. J. Creeth, Hannah R. Tyson, Raquel Boque-Sastre, Anthony R. Isles, Rupert Palme, Chadi Touma, Rosalind M. John   +7 more
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Abrupt transitions in time series with uncertainties

Nature Communications, 2018
Most time series techniques tend to ignore data uncertainties, which results in inaccurate conclusions. Here, Goswami et al. represent time series as a sequence of probability density functions, and reliably detect abrupt transitions by identifying ...
Bedartha Goswami, Niklas Boers, Aljoscha Rheinwalt, Norbert Marwan, Jobst Heitzig, Sebastian F. M. Breitenbach, Jürgen Kurths   +6 more
doaj   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Strategies to implement evidence-informed decision making at the organizational level: a rapid systematic review

BMC Health Services Research
Background Achievement of evidence-informed decision making (EIDM) requires the integration of evidence into all practice decisions by identifying and synthesizing evidence, then developing and executing plans to implement and evaluate changes to ...
Emily C. Clark, Trish Burnett, Rebecca Blair, Robyn L. Traynor, Leah Hagerman, Maureen Dobbins   +5 more
doaj   +1 more source

IDENTIFICATION, DISTRIBUTION, AND TESTING THE LEVEL OF Sternochetus (Sternochetus sp, COLEOPTERA: CURCULIONIDAE) ATTACK AND THE HOST STATUS USING NO-CHOICE TEST

Jurnal Hama dan Penyakit Tumbuhan Tropika, 2019
Mango pulp weevil (MPW) and mango seed weevil (MSW) are found in only three species in the world, namely Sternochetus frigidus (MPW), Sternochetus mangiferae (MSW) and Sternochetus olivieri (MSW).
Ade Syahputra, Mustopha Ahad, Abdurakhman .,, Joni Hidayat   +3 more
doaj   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source