Results 71 to 80 of about 33,945,293 (343)

Approximate Bayesian Computational methods

, 2011
Also known as likelihood-free methods, approximate Bayesian computational (ABC) methods have appeared in the past ten years as the most satisfactory approach to untractable likelihood problems, first in genetics then in a broader spectrum of applications.
Marin, Jean-Michel, Pudlo, Pierre, Robert, Christian P., Ryder, Robin   +3 more
core   +3 more sources

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

SpiDa-MRI: behavioral and (f)MRI data of adults with fear of spiders

Scientific Data
Neuroimaging has greatly improved our understanding of phobic mechanisms. To expand on these advancements, we present data on the heterogeneity of neural patterns in spider phobia combined with various psychological dimensions of spider phobia, using ...
Mengfan Zhang, Alexander Karner, Kathrin Kostorz, Sophia Shea, David Steyrl, Filip Melinscak, Ronald Sladky, Cindy Sumaly Lor, Frank Scharnowski   +8 more
doaj   +1 more source

Abrupt transitions in time series with uncertainties

Nature Communications, 2018
Most time series techniques tend to ignore data uncertainties, which results in inaccurate conclusions. Here, Goswami et al. represent time series as a sequence of probability density functions, and reliably detect abrupt transitions by identifying ...
Bedartha Goswami, Niklas Boers, Aljoscha Rheinwalt, Norbert Marwan, Jobst Heitzig, Sebastian F. M. Breitenbach, Jürgen Kurths   +6 more
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

Promoting awareness of key resources for evidence-informed decision making in public health: An evaluation of a webinar series about knowledge translation methods and tools

Frontiers in Public Health, 2016
The National Collaborating Centre for Methods and Tools (NCCMT) has developed several resources to support evidence-informed decision making – the process of distilling and disseminating best available evidence from research, context and experience – and
Jennifer eYost, Jeannie eMackintosh, Kristin eRead, Maureen eDobbins   +3 more
doaj   +1 more source

Methods in Psychological Research [PDF]

, 2002
Psychologists collect empirical data with various methods for different reasons. These diverse methods have their strengths as well as weaknesses. Nonetheless, it is possible to rank them in terms of different critieria.
Chow, Siu L.
core  

Methods for Reliable Teleportation

, 1998
Recent experimental results and proposals towards implementation of quantum teleportation are discussed. It is proved that reliable (theoretically, 100% probability of success) teleportation cannot be achieved using the methods applied in recent ...
A. Furusawa, B. Bouwmeester, C. H. Bennett, D. Boschi, H. Weinfurter, J. I. Cirac, J. W. Pan, K. Mattle, L. Davidovich, L. Vaidman, Lev Vaidman, M. H. Y. Moussa, M. Michler, N. G. Almeida, Nadav Yoran, S. B. Zheng, S. Braunstein, S. Haroche, S. L. Braunstein, S. N. Molotkov, T. Sleator, Y. Aharonov   +21 more
core   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

Strategies to implement evidence-informed decision making at the organizational level: a rapid systematic review

BMC Health Services Research
Background Achievement of evidence-informed decision making (EIDM) requires the integration of evidence into all practice decisions by identifying and synthesizing evidence, then developing and executing plans to implement and evaluate changes to ...
Emily C. Clark, Trish Burnett, Rebecca Blair, Robyn L. Traynor, Leah Hagerman, Maureen Dobbins   +5 more
doaj   +1 more source