Results 101 to 110 of about 1,260,485 (295)

Newton's Method and the Jenkins-Traub Algorithm [PDF]

open access: yesProceedings of the American Mathematical Society, 1986
In this paper we propose to show how a multi-increment version of Newton’s method can be used to obtain starting points for the Jenkins-Traub algorithm.
openaire   +2 more sources

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

open access: yesMolecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez   +5 more
wiley   +1 more source

Machine learning methods in chemoinformatics [PDF]

open access: yes, 2014
Machine learning algorithms are generally developed in computer science or adjacent disciplines and find their way into chemical modeling by a process of diffusion.
John B. O. Mitchell, Mitchell, J.B.O.
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

A Divisive Initialisation Method for Clustering Algorithms [PDF]

open access: yes, 1999
A method for the initialisation step of clustering algorithms is presented. It is based on the concept of cluster as a high density region of points. The search space is modelled as a set of d-dimensional cells. A sample of points is chosen and located into the appropriate cells.
Pizzuti Clara   +2 more
openaire   +2 more sources

Genetic and memetic algorithms for scheduling railway maintenance activities [PDF]

open access: yes
Nowadays railway companies are confronted with high infrastructure maintenance costs. Therefore good strategies are needed to carry out these maintenance activities in a most cost effective way.
Dekker, R., Kaymak, U., Budai-Balke, G.
core  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

open access: yesMolecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu   +9 more
wiley   +1 more source

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