Results 101 to 110 of about 1,090,569 (315)

Recent advances in computational materials design: methods, applications, algorithms, and informatics. [PDF]

J Mater Sci, 2022
Pilania G, Goldsmith BR, Yoon M, Dongare AM.   +3 more
europepmc   +1 more source

Machine learning methods in chemoinformatics

, 2014
Machine learning algorithms are generally developed in computer science or adjacent disciplines and find their way into chemical modeling by a process of diffusion.
John B. O. Mitchell, Mitchell, J.B.O.
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

A Method to Accelerate the Convergence of the Secant Algorithm [PDF]

Advances in Numerical Analysis, 2014
We present an acceleration technique for the Secant method. The Secant method is a root-searching algorithm for a general function f. We exploit the fact that the combination of two Secant steps leads to an improved, so-called first-order approximant of the root. The original Secant algorithm can be modified to a first-order accelerated algorithm which
openaire   +2 more sources

Automated Model Inference for Gaussian Processes: An Overview of State-of-the-Art Methods and Algorithms. [PDF]

SN Comput Sci, 2022
Berns F, Hüwel J, Beecks C.
europepmc   +1 more source

Comparison of Direct Multiobjective Optimization Methods for the Design of Electric Vehicles [PDF]

, 2006
"System design oriented methodologies" are discussed in this paper through the comparison of multiobjective optimization methods applied to heterogeneous devices in electrical engineering.
Régnier, Jérémi, Sareni, Bruno, Roboam, Xavier, Fefermann, Yan   +3 more
core  

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Rethinking the Methods and Algorithms for Inner Speech Decoding and Making Them Reproducible. [PDF]

NeuroSci, 2022
Simistira Liwicki F, Gupta V, Saini R, De K, Liwicki M.   +4 more
europepmc   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

MACHINE LEARNING METHODS IN DIGITAL AGRICULTURE: ALGORITHMS AND CASES

International Journal of Advanced Studies, 2018
Ensuring food security is a major challenge in many countries. With a growing global population, the issues of improving the efficiency of agriculture have become most relevant.
Aleksandr Vasilyevich Koshkarov
doaj   +1 more source