Results 81 to 90 of about 1,260,485 (295)

Intercomparisons of Long-Term Atmospheric Temperature and Humidity Profile Retrievals

open access: yesRemote Sensing, 2019
This study builds upon a framework to develop a climate data record of temperature and humidity profiles from high-resolution infrared radiation sounder (HIRS) clear-sky measurements.
Jessica L. Matthews, Lei Shi
doaj   +1 more source

Explicit memory schemes for evolutionary algorithms in dynamic environments [PDF]

open access: yes, 2007
Copyright @ 2007 Springer-VerlagProblem optimization in dynamic environments has atrracted a growing interest from the evolutionary computation community in reccent years due to its importance in real world optimization problems.
Yang, S   +2 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

open access: yesMolecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir   +13 more
wiley   +1 more source

Algorithm Development of Temperature and Humidity Profile Retrievals for Long-Term HIRS Observations

open access: yesRemote Sensing, 2016
A project for deriving temperature and humidity profiles from High-resolution Infrared Radiation Sounder (HIRS) observations is underway to build a long-term dataset for climate applications.
Lei Shi   +4 more
doaj   +1 more source

Algorithms and methods in differential algebra

open access: yesTheoretical Computer Science, 1996
The first three sections provide a rather superficial survey of Risch theory, i.e., solving \(y'=f\) by elementary functions, and symbolically solving linear \(n\)th order differential equations. The sections 4 and 5 give a survey of problems related to polynomial vector fields \(V=V_x\partial_x+V_y\partial_y+V_z\partial_z\), with \(V_x,V_y,V_z\in ...
openaire   +2 more sources

Genetic Algorithms: Genesis of Stock Evaluation [PDF]

open access: yes
The uncertainty of predicting stock prices emanates pre-eminent concerns around the functionality of the stock market. The possibility of utilising Genetic Algorithms to forecast the momentum of stock price has been previously explored by many ...
Rama Prasad Kanungo
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

A Method to Accelerate the Convergence of the Secant Algorithm [PDF]

open access: yesAdvances in Numerical Analysis, 2014
We present an acceleration technique for the Secant method. The Secant method is a root-searching algorithm for a general function f. We exploit the fact that the combination of two Secant steps leads to an improved, so-called first-order approximant of the root. The original Secant algorithm can be modified to a first-order accelerated algorithm which
openaire   +3 more sources

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