Results 131 to 140 of about 1,260,485 (295)

GLOBAL OPTIMIZATION METHODS [PDF]

open access: yes
Training a neural network is a difficult optimization problem because of numerous local minimums. Many global search algorithms have been used to train neural networks. However, local search algorithms are more efficient with computational resources, and
Brorsen, B. Wade, Hamm, Lonnie
core  

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

open access: yesFEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer   +7 more
wiley   +1 more source

COMPETITIVE MECHANISMS FOR FINANCING INNOVATION AND INVESTMENT PROJECTS

open access: yesМодернизация, инновация, развитие, 2016
The article deals with the organizational and methodological basis for the formation of competitive technologies and innovative fi nancing mechanisms and investment projects.
N. I. Komkov   +3 more
doaj  

PASSWORD HASHING METHODS AND ALGORITHMS ON THE .NET PLATFORM

open access: yesСучасні інформаційні системи
Web applications, which are widely used to provide services and collect information, have become a major target for attackers, especially with the emergence of government services that process sensitive data.
Volodymyr Fedorchenko   +4 more
doaj   +1 more source

Heuristic estimates in shortest path algorithms [PDF]

open access: yes
Shortest path problems occupy an important position in Operations Research aswell as in Arti¯cial Intelligence. In this paper we study shortest path algorithms thatexploit heuristic estimates. The well-known algorithms are put into one framework.Besides
Pijls, W.H.L.M.
core  

Comparison of Direct Multiobjective Optimization Methods for the Design of Electric Vehicles [PDF]

open access: yes, 2006
"System design oriented methodologies" are discussed in this paper through the comparison of multiobjective optimization methods applied to heterogeneous devices in electrical engineering.
Régnier, Jérémi   +3 more
core  

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

open access: yesFEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey   +4 more
wiley   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

open access: yesAging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi   +3 more
wiley   +1 more source

RNA Sequencing Resolves Cryptic Pathogenic Variants in Mitochondrial Disease

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Mitochondrial diseases are the most common inherited metabolic disorders, characterized by pronounced clinical and genetic heterogeneity that complicates molecular diagnosis. Although DNA‐based sequencing approaches have become standard in genetic testing, up to half of patients remain without a definitive diagnosis.
Zhimei Liu   +21 more
wiley   +1 more source

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