Results 1 to 10 of about 672,794 (243)

Diagnostic Practices and Treatment for P. vivax in the InterEthnic Therapeutic Encounter of South-Central Vietnam: A Mixed-Methods Study [PDF]

Pathogens, 2020
Malaria elimination in the Greater Mekong Sub-Region is challenged by a rising proportion of malaria attributable to P. vivax. Primaquine (PQ) is effective in eliminating the parasite’s dormant liver stages and can prevent relapsing infections, but it induces severe haemolysis in patients with Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency ...
Nguyen, TT, Nguyen, XX, Ronse, M, Nguyen, QT, Ho, PQ, Tran, DT, Gerrets, R, Thriemer, K, Ley, B, Marfurt, J, Price, RN, Grietens, KP, Gryseels, C   +12 more
openaire   +6 more sources

The challenges with the validation of research antibodies [version 1; referees: 2 approved]

F1000Research, 2017
This article further discusses the reproducibility crisis in biomedical science and how poor conduct of commercial antibodies contribute to this. In addition, the way quality data are presented on product sheets by antibody vendors is scrutinized.
Jan L.A. Voskuil
doaj   +1 more source

Monocytes isolated by positive and negative magnetic sorting techniques show different molecular characteristics and immunophenotypic behaviour [version 3; referees: 2 approved]

F1000Research, 2018
Background: Magnetic sorting of cells, based on  microbead conjugated antibodies (Abs), employs positive as well as negative immunomagnetic separation methods, for isolation of a specific cell population.
Jashdeep Bhattacharjee, Barun Das, Alaknanda Mishra, Preeti Sahay, Pramod Upadhyay   +4 more
doaj   +1 more source

Characterisation of a stably integrated expression system for exogenous protein expression in DT40 [version 2; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2017
The use of constitutive promoters to drive exogenous protein expression is an important tool for the study of diverse biological processes. To create and characterise a stably integrated expression system for DT40 cells, we constructed integration ...
Meliti Skouteri, Helfrid Hochegger, Antony M. Carr   +2 more
doaj   +1 more source

Impact of detecting potentially serious incidental findings during multi-modal imaging [version 3; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2018
Background: There are limited data on the impact of feedback of incidental findings (IFs) from research imaging.  We evaluated the impact of UK Biobank’s protocol for handling potentially serious IFs in a multi-modal imaging study of 100,000 participants
Lorna M Gibson, Thomas J Littlejohns, Ligia Adamska, Steve Garratt, Nicola Doherty, UK Biobank Imaging Working Group, Joanna M Wardlaw, Giles Maskell, Michael Parker, Roger Brownsword, Paul M Matthews, Rory Collins, Naomi E Allen, Jonathan Sellors, Cathie LM Sudlow   +14 more
doaj   +1 more source

Characterisation of a stably integrated expression system for exogenous protein expression in DT40 [version 1; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2017
The use of constitutive promoters to drive exogenous protein expression is an important tool for the study of diverse biological processes. To create and characterise a stably integrated expression system for DT40 cells, we constructed integration ...
Meliti Skouteri, Helfrid Hochegger, Antony M. Carr   +2 more
doaj   +1 more source

MicroRNA levels quantified in whole blood varies from PBMCs [version 4; referees: 2 approved, 1 not approved]

F1000Research, 2015
MicroRNAs are non-coding RNAs that negatively regulate mRNA expression and play significant roles in both health and disease. Differential microRNA expression has been used to aid diagnosis and discriminate disease stages. The accuracy and reliability of
Sadaf Atarod, Hannah Smith, Anne Dickinson, Xiao-Nong Wang   +3 more
doaj   +1 more source

Method of studying depth distribution of therapeutic and diagnostic substances inside spherical amorphous nanoparticles

Nanotechnologies in Russia, 2010
A method for investigating the distribution of therapeutic and diagnostic substances inside nanoparticles was developed for spherical amorphous nanoparticles (SANPs). SANPs were generated from the lupan triterpenoids of birch bark (LTs). This method was based on the sequence of short exposures of SANPs in a special solvent.
Khlebnikov V.K., Boguslavsky L.I., Popenko V.I., Kaplun A.P., Shvets V.I.   +4 more
openaire   +3 more sources

Impact of detecting potentially serious incidental findings during multi-modal imaging [version 2; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2018
Background: There are limited data on the impact of feedback of incidental findings (IFs) from research imaging.  We evaluated the impact of UK Biobank’s protocol for handling potentially serious IFs in a multi-modal imaging study of 100,000 participants
Lorna M Gibson, Thomas J Littlejohns, Ligia Adamska, Steve Garratt, Nicola Doherty, UK Biobank Imaging Working Group, Joanna M Wardlaw, Giles Maskell, Michael Parker, Roger Brownsword, Paul M Matthews, Rory Collins, Naomi E Allen, Jonathan Sellors, Cathie LM Sudlow   +14 more
doaj   +1 more source

A simple method to measure CLOCK-BMAL1 DNA binding activity in tissue and cell extracts [version 2; referees: 2 approved, 1 approved with reservations]

F1000Research, 2017
The proteins CLOCK and BMAL1 form a heterodimeric transcription factor essential to circadian rhythms in mammals.  Daily rhythms of CLOCK-BMAL1 DNA binding activity are known to oscillate with target gene expression in vivo.
Maud Gillessen, Pieter Bas Kwak, Alfred Tamayo   +2 more
doaj   +1 more source