Results 11 to 20 of about 672,794 (243)
F1000Research, 2017 The proteins CLOCK and BMAL1 form a heterodimeric transcription factor essential to circadian rhythms in mammals. Daily rhythms of CLOCK-BMAL1 DNA binding activity are known to oscillate with target gene expression in vivo.
Maud Gillessen +2 more
doaj +1 more source
Commercial antibodies and their validation [v2; ref status: indexed, http://f1000r.es/4jp]
F1000Research, 2014 Despite an impressive growth in the business of research antibodies a general lack of trust in commercial antibodies remains in place. A variety of issues, each one potentially causing an antibody to fail, underpin the frustrations that scientists endure.
JLA Voskuil
doaj +1 more source
F1000Research, 2013 Background: Regulatory decision-making involves assessment of risks and benefits of medications at the time of approval or when relevant safety concerns arise with a medication.
Nisa M Maruthur +5 more
doaj +1 more source
F1000Research, 2018 3',6-dimethoxy-3'',4''-(methylenedioxy)-2,5-epoxylignan-4'-ol (DMEO), an epoxylignan isolated from Piper nigrum, has currently captured attention for its potential antitumor effect. However, low stability is limiting its therapeutic application.
Yusnita Rifai +4 more
doaj +1 more source
Commercial antibodies and their validation [v1; ref status: indexed, http://f1000r.es/43b]
F1000Research, 2014 Despite an impressive growth in the business of research antibodies a general lack of trust in commercial antibodies remains in place. A variety of issues, each one potentially causing an antibody to fail, underpin the frustrations that scientists endure.
JLA Voskuil
doaj +1 more source
F1000Research, 2017 Background: Magnetic sorting of cells, based on microbead conjugated antibodies (Abs), employs positive as well as negative immunomagnetic separation methods, for isolation of a specific cell population.
Jashdeep Bhattacharjee +4 more
doaj +1 more source
F1000Research, 2015 MicroRNAs are non-coding RNAs that negatively regulate mRNA expression and play significant roles in both health and disease. Differential microRNA expression has been used to aid diagnosis and discriminate disease stages. The accuracy and reliability of
Sadaf Atarod +3 more
doaj +1 more source
F1000Research, 2017 Finding an antibody that works for a specific application can be a difficult task. Hundreds of vendors offer millions of antibodies, but the quality of these products and available validation information varies greatly.
Poulomi Acharya +2 more
doaj +1 more source
F1000Research, 2015 Oral appliance (OA) therapy with a mandibular advancement device (OAm) is a non-invasive, alternative approach to maintaining upper airway patency. The main requirement for an OAm to be effective is the adequate retention on the teeth while the patient ...
Marc Braem
doaj +1 more source
Exploring the Diagnostic and Therapeutic Pathways of Women with Dyspareunia: A Mixed-Methods Study
Journal of Clinical MedicineBackground/Objectives: This study explores the diagnostic and management pathways for dyspareunia in women seeking specialist care, focusing on gynecologists’ feedback and women’s perceptions of their experience. Methods: An online survey was conducted among 225 sexually active women to explore their perceptions of dyspareunia, its impact on ...
Joanna Wojtas +3 more
openaire +3 more sources