Results 61 to 70 of about 8,655,350 (264)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Adsorption of Benzene, Toluene, Ethylbenzene and o-Xylene by Carbon-Based Adsorbents

open access: yesEurasian Chemico-Technological Journal, 2016
This study explored the possibility of applying different carbon-based adsorbents for removal of benzene, toluene, ethylbenzene and o-xylene (BTEX) from indoor air in static and dynamic modes.
N. Baimatova   +3 more
doaj   +1 more source

Conductive Polymer/SiO2 Composite as an Anticorrosive Coating Against Carbon Dioxide Corrosion of Mild Steel. A Simulation Study

open access: yesEurasian Chemico-Technological Journal, 2020
In this work corrosion of mild steel affected by carbon dioxide was studied using a simulation model developed by Nordsveen M. and Nesic S. Using this comprehensive model of the uniform corrosion made possible to predict of corrosion rate of steel in ...
K. Avchukir, B. D. Burkitbayeva
doaj   +1 more source

Combinatorial methods in analysis

open access: yesDiscrete Mathematics, 2001
The aim of the paper is to present the proof and various applications of a weall-known lemma due to the author [Czech. Math. J. 9 (84), 629-630 (1959; Zbl 0093.05601)].
openaire   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

GeFaST: An improved method for OTU assignment by generalising Swarm’s fastidious clustering approach

open access: yesBMC Bioinformatics, 2018
Background Massive genomic data sets from high-throughput sequencing allow for new insights into complex biological systems such as microbial communities. Analyses of their diversity and structure are typically preceded by clustering millions of 16S rRNA
Robert Müller, Markus E. Nebel
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

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