Results 261 to 270 of about 158,419 (290)
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Clinical and Experimental Dermatology, 1996
Methotrexate is an effective antipsoriatic agent and has been widely used to treat severe psoriasis since the 1960s. It is especially useful in acute generalized pustular psoriasis, psoriatic erythroderma, psoriatic arthritis and for extensive chronic plaque psoriasis in patients who are inadequately controlled by topical therapy alone.
M. J. Boffa, R.J.G. Chalmers
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Methotrexate is an effective antipsoriatic agent and has been widely used to treat severe psoriasis since the 1960s. It is especially useful in acute generalized pustular psoriasis, psoriatic erythroderma, psoriatic arthritis and for extensive chronic plaque psoriasis in patients who are inadequately controlled by topical therapy alone.
M. J. Boffa, R.J.G. Chalmers
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Dermatologic Therapy, 2007
Methotrexate is a folic acid analog pioneered for use in inflammatory diseases by dermatologists, and used successfully for over 40 years for a wide variety of cutaneous diseases. In addition to its antiproliferative properties, methotrexate has other more recently recognized anti-inflammatory properties related to its effects on adenosine.
Melissa I Costner, Carolyn A. Bangert
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Methotrexate is a folic acid analog pioneered for use in inflammatory diseases by dermatologists, and used successfully for over 40 years for a wide variety of cutaneous diseases. In addition to its antiproliferative properties, methotrexate has other more recently recognized anti-inflammatory properties related to its effects on adenosine.
Melissa I Costner, Carolyn A. Bangert
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The pharmacology of methotrexate
Expert Opinion on Pharmacotherapy, 2001Ectopic pregnancy (EP) is a major cause of maternal morbidity and mortality. The treatment of this condition is primarily surgical, but medical management in selected cases is safe, effective, cost-effective and eliminates the morbidity of surgery.
Christos Coutifaris +2 more
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JAMA: The Journal of the American Medical Association, 1969
To the Editor.— The editorial ( 212 : 314, 1970) on psoriasis, methotrexate, and cirrhosis presents a cogent and balanced approach to the treatment of a patient with a long-term and recurrent problem. We feel that one statement ("... indications are expanding to include milder degrees of involvement where only cosmetic inconvenience exists") may be ...
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To the Editor.— The editorial ( 212 : 314, 1970) on psoriasis, methotrexate, and cirrhosis presents a cogent and balanced approach to the treatment of a patient with a long-term and recurrent problem. We feel that one statement ("... indications are expanding to include milder degrees of involvement where only cosmetic inconvenience exists") may be ...
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International Journal of Radiation Oncology*Biology*Physics, 1978
INTRODUCTION Methotrexate is an anatlogue of aminopterin which was first used in the treatment of acute leukaemia in 1947. However, because of its better therapeutic index, the closely related amethopterin superseded aminopterin and was marketed as Methotrexate.
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INTRODUCTION Methotrexate is an anatlogue of aminopterin which was first used in the treatment of acute leukaemia in 1947. However, because of its better therapeutic index, the closely related amethopterin superseded aminopterin and was marketed as Methotrexate.
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Journal of Allergy and Clinical Immunology, 1991
Recent trials of low-dosage methotrexate in chronic steroid-dependent asthma have engendered considerable interest and debate. It is still too early to say whether the variable sterold-sparlng effects In the reports to date will be found In other controlled studies underway.
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Recent trials of low-dosage methotrexate in chronic steroid-dependent asthma have engendered considerable interest and debate. It is still too early to say whether the variable sterold-sparlng effects In the reports to date will be found In other controlled studies underway.
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Pharmacogenetics of methotrexate
Pharmacogenomics, 2004Methotrexate (MTX) has proven efficient in the treatment of a number of malignancies, as well as non-malignant disorders characterized by a rapid cellular growth. Yet some patients might develop resistance, while others could have toxic side effects. MTX achieves its cytotoxicity through the inhibition of folate-dependent enzymes, suggesting that the ...
Maja Krajinovic, Albert Moghrabi
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Clinical and experimental rheumatology, 2010
The clinical relevance of the concept of bioavailability rests on two main principles. First, that measurement of the active component at the site of action is generally not possible and, secondly, that a relationship exists between on the one hand efficacy and/or safety and on the other hand concentration of the active compound or its active ...
van Roon, E.N., van de Laar, Mart A F J
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The clinical relevance of the concept of bioavailability rests on two main principles. First, that measurement of the active component at the site of action is generally not possible and, secondly, that a relationship exists between on the one hand efficacy and/or safety and on the other hand concentration of the active compound or its active ...
van Roon, E.N., van de Laar, Mart A F J
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Current Opinion in Rheumatology, 2009
Methotrexate (MTX) has been used for the treatment of rheumatoid arthritis (RA) for about three decades now. MTX is one of the most effective and commonly used medicines to treat various forms of arthritis and other rheumatic conditions. MTX was shown to improve signs and symptoms of RA, disease activity and function, to a similar degree as the tumor ...
Juergen Braun, Rolf Rau
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Methotrexate (MTX) has been used for the treatment of rheumatoid arthritis (RA) for about three decades now. MTX is one of the most effective and commonly used medicines to treat various forms of arthritis and other rheumatic conditions. MTX was shown to improve signs and symptoms of RA, disease activity and function, to a similar degree as the tumor ...
Juergen Braun, Rolf Rau
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Annals of Internal Medicine, 1969
Excerpt To the Editor:I was disturbed to read the recent article by Dr. Mortimer Lacher (Spontaneous Remission or Response of Sarcoidosis to Methotrexate,Ann. Intern, Med. 69: 1247, 1968).
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Excerpt To the Editor:I was disturbed to read the recent article by Dr. Mortimer Lacher (Spontaneous Remission or Response of Sarcoidosis to Methotrexate,Ann. Intern, Med. 69: 1247, 1968).
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