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British Journal of Dermatology, 1968
SUMMARY. Seventeen patients with widespread psoriasis were treated with parenteral methotrexate over a period of 2–88 weeks. The injections were given every 1–4 weeks, in a dose of 12·5–37·5 mg. The best results were obtained with a dose of 25 mg. of methotrexate once weekly.
M, Schewach-Millet, L, Ziprkowski
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SUMMARY. Seventeen patients with widespread psoriasis were treated with parenteral methotrexate over a period of 2–88 weeks. The injections were given every 1–4 weeks, in a dose of 12·5–37·5 mg. The best results were obtained with a dose of 25 mg. of methotrexate once weekly.
M, Schewach-Millet, L, Ziprkowski
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Best Practice & Research Clinical Obstetrics & Gynaecology, 2023
Expectant management of a cesarean scar pregnancy (CSP) is associated with a high risk of severe maternal morbidity. Therefore, most experts recommend immediate termination after the diagnosis of a CSP. However, there is no consensus about the optimal management of a CSP in terms of efficacy, safety, and preservation of future fertility.
NOEL, Laure, Chantraine, Frédéric
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Expectant management of a cesarean scar pregnancy (CSP) is associated with a high risk of severe maternal morbidity. Therefore, most experts recommend immediate termination after the diagnosis of a CSP. However, there is no consensus about the optimal management of a CSP in terms of efficacy, safety, and preservation of future fertility.
NOEL, Laure, Chantraine, Frédéric
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Home Healthcare Now, 2015
The purpose of this article is to educate healthcare professionals about the many uses of the drug Methotrexate. Information regarding dosing, action, contraindications, adverse effects, drug interactions, as well as tips for patient education are included.
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The purpose of this article is to educate healthcare professionals about the many uses of the drug Methotrexate. Information regarding dosing, action, contraindications, adverse effects, drug interactions, as well as tips for patient education are included.
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Clinical and Experimental Dermatology, 1996
Methotrexate is an effective antipsoriatic agent and has been widely used to treat severe psoriasis since the 1960s. It is especially useful in acute generalized pustular psoriasis, psoriatic erythroderma, psoriatic arthritis and for extensive chronic plaque psoriasis in patients who are inadequately controlled by topical therapy alone.
M J, Boffa, R J, Chalmers
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Methotrexate is an effective antipsoriatic agent and has been widely used to treat severe psoriasis since the 1960s. It is especially useful in acute generalized pustular psoriasis, psoriatic erythroderma, psoriatic arthritis and for extensive chronic plaque psoriasis in patients who are inadequately controlled by topical therapy alone.
M J, Boffa, R J, Chalmers
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Skeletal Radiology, 1984
Methotrexate osteopathy is an uncommon complication of long-term oral maintenance therapy for childhood neoplasms, most commonly acute lymphocytic leukemia. It is characterized by severe lower extremity pain and by osteoporosis particularly involving the lower extremities and thick dense provisional zones of calcification and growth arrest lines ...
A M, Schwartz, J C, Leonidas
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Methotrexate osteopathy is an uncommon complication of long-term oral maintenance therapy for childhood neoplasms, most commonly acute lymphocytic leukemia. It is characterized by severe lower extremity pain and by osteoporosis particularly involving the lower extremities and thick dense provisional zones of calcification and growth arrest lines ...
A M, Schwartz, J C, Leonidas
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The Journal of Dermatology, 1999
AbstractMethotrexate (MTX) nodulosis in patients with rheumatoid arthritis treated with MTX has become a well recognized phenomenon. It has not been described in patients receiving MTX for treatment of other diseases, e.g., dermatological or malignant diseases. Recently, MTX nodulosis was described in a patient with psoriasis and arthritis.
K A, Jang +5 more
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AbstractMethotrexate (MTX) nodulosis in patients with rheumatoid arthritis treated with MTX has become a well recognized phenomenon. It has not been described in patients receiving MTX for treatment of other diseases, e.g., dermatological or malignant diseases. Recently, MTX nodulosis was described in a patient with psoriasis and arthritis.
K A, Jang +5 more
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Journal of Allergy and Clinical Immunology, 1991
Recent trials of low-dosage methotrexate in chronic steroid-dependent asthma have engendered considerable interest and debate. It is still too early to say whether the variable sterold-sparlng effects In the reports to date will be found In other controlled studies underway.
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Recent trials of low-dosage methotrexate in chronic steroid-dependent asthma have engendered considerable interest and debate. It is still too early to say whether the variable sterold-sparlng effects In the reports to date will be found In other controlled studies underway.
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Pharmacogenetics of methotrexate
Pharmacogenomics, 2004Methotrexate (MTX) has proven efficient in the treatment of a number of malignancies, as well as non-malignant disorders characterized by a rapid cellular growth. Yet some patients might develop resistance, while others could have toxic side effects. MTX achieves its cytotoxicity through the inhibition of folate-dependent enzymes, suggesting that the ...
Maja, Krajinovic, Albert, Moghrabi
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International Journal of Radiation Oncology*Biology*Physics, 1978
INTRODUCTION Methotrexate is an anatlogue of aminopterin which was first used in the treatment of acute leukaemia in 1947. However, because of its better therapeutic index, the closely related amethopterin superseded aminopterin and was marketed as Methotrexate.
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INTRODUCTION Methotrexate is an anatlogue of aminopterin which was first used in the treatment of acute leukaemia in 1947. However, because of its better therapeutic index, the closely related amethopterin superseded aminopterin and was marketed as Methotrexate.
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The pharmacology of methotrexate
Journal of the American Academy of Dermatology, 1991Methotrexate is a useful antimetabolite for the treatment of both benign and malignant proliferative disorders. When the pharmacokinetics and potential toxicity of this drug are understood, treatment regimens can be tailored to the underlying kinetics of the target population.
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