Results 271 to 280 of about 158,419 (290)
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ChemInform Abstract: ANALOGUES OF METHOTREXATE
Chemischer Informationsdienst, 1979AbstractÜber eine Alkylierung mit 6‐(Brommethyl)‐2,4‐pteridindiamin und Analoge und (teilweise) Verseifung werden die Verbindungen (II) bis (V) in Ausbeuten bis zu 97% dargestellt.
Carroll Temple +5 more
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Pharmacokinetics of 7‐Hydroxy‐methotrexate and Methotrexate in the Rat
Pharmacology & Toxicology, 1988Abstract: To investigate the pharmacokinetics of the active metabolite of methotrexate (MTX), 7‐hydroxy‐methotrexate (7‐OH‐MTX), 1 mg/kg of the compound was administered as single intravenous bolus injections to 6 unanaestetized rats. For comparison, 1 mg/kg of the parent drug MTX was given to the same number of animals.
Jarle Aarbakke +3 more
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The pharmacology of methotrexate
Journal of the American Academy of Dermatology, 1991Methotrexate is a useful antimetabolite for the treatment of both benign and malignant proliferative disorders. When the pharmacokinetics and potential toxicity of this drug are understood, treatment regimens can be tailored to the underlying kinetics of the target population.
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JAMA: The Journal of the American Medical Association, 1973
The therapy of severe refractory psoriasis with the folic acid antagonist, methotrexate, recently received Food and Drug Administration approval. The folic acid antagonists were first used for psoriasis in 1951, and since then an extensive literature has attested the efficacy of methotrexate for treating various forms of psoriasis and psoriatic ...
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The therapy of severe refractory psoriasis with the folic acid antagonist, methotrexate, recently received Food and Drug Administration approval. The folic acid antagonists were first used for psoriasis in 1951, and since then an extensive literature has attested the efficacy of methotrexate for treating various forms of psoriasis and psoriatic ...
openaire +3 more sources