Results 61 to 70 of about 52,767 (240)

Pollinators, “mustard oil” volatiles, and fruit production in flowers of the dioecious tree Drypetes natalensis (Putranjivaceae) [PDF]

, 2009
The Putranjivaceae is an enigmatic family, notable for being the only lineage outside the Capparales to possess the glucosinolate biochemical pathway, which forms the basis of an induced chemical defense system against herbivores (the “ mustard oil bomb ”
Griffiths, M E, Johnson, S D, Lawes, M J, Peter, C I   +3 more
core   +2 more sources

Dual‐Key Genetic Circuit Enables Stable and Self‐Regulated Engineered Bacteria for the Treatment of Ulcerative Colitis

Advanced Science, EarlyView.
A self‐regulated Escherichia coli Nissle 1917 strain equipped with a dual‐key genetic circuit achieved antibiotic‐free stability and programmable lysis for therapeutic protein delivery. By co‐expressing an IL‐2 mutant and Amuc_1100, the engineered bacteria restored immune balance and epithelial integrity, providing a safe and precise approach for ...
Shuaijie Ding, Biao Yang, Xinyu Li, Yi Wang, Chunyu Huang, Wenfei Dong, Wei Xie   +6 more
wiley   +1 more source

Synthesis, structure and properties of N-R-2-(5-(5-methyl-1H-pyrazole-3-yl)-4-phenyl-4H-1,2,4-triazole-3-ylthio)acetamides

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2019
Heterocyclic compounds remain the most promising group of compounds, through which the new drugs with characteristic list of properties are successfully created. Examples of this systems are 1,2,4-triazole and pyrazole.
A. S. Hotsulia, S. O. Fedotov
doaj   +1 more source

Volatile Flavor Compounds of Pugionium cornutum (L.) Gaertn. Before and After Different Dehydration Treatments

Frontiers in Nutrition, 2022
Pugionium cornutum (L.) Gaertn (also Pugionium) is a special Mongolian vegetable, belonging to the Cruciferous family, growing in arid and semi-arid areas of northern China, with a unique flavor and potential health benefits.
Haoyu Li, Haoyu Li, Qian Wu, Qiannan Liu, Lihua Jin, Bang Chen, Cong Li, Jianbo Xiao, Yehua Shen   +8 more
doaj   +1 more source

6-Methylsulfinylhexyl isothiocyanate activates carbonic anhydrase-dependent HCO₃ ^-/H⁺/Na⁺/Ca²⁺ transport via SLC4As-NHE-NCX-PMCA axis in odontoblasts. [PDF]

J Physiol
Abstract figure legend 6‐Methylsulfinylhexyl isothiocyanate (6‐MSITC, hexaraphane), a wasabi sulfinyl compound, activates intracellular carbonic anhydrase (CA)‐mediated sequential HCO3−, Na+, H+ and Ca2+ transport through an activation axis involving HCO3−‐transporting solute carrier family 4 (SLC4As), the Na+–H+ exchanger (NHE), the Na+–Ca2+ exchanger
Furusawa Y, Kimura M, Okunishi I, Ouchi T, Kurashima R, Katou-Yamada T, Kuroda H, Sugita M, Furusawa M, Shibukawa Y.   +9 more
europepmc   +2 more sources

Diphenylmethyl isothiocyanate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
The asymmetric unit of the title compound, C(14)H(11)NS, contains two mol-ecules in which the dihedral angles between the phenyl rings are 77.23 (7) and 86.30 (7)°. No aromatic π-π stacking inter-actions are observed.
Pei-Hua Zhao, Jun-Jie Liu, Mei Zhang, Gui-Zhe Zhao, Ya-Qing Liu   +4 more
openaire   +3 more sources

Piezo1 Channel Mediates Mechanically Programmable Drug Delivery to Potentiate Intravesical Chemotherapy

Advanced Science, EarlyView.
This study utilizes programmable mechanical pressure as a therapeutic enhancer to establish a mechano‐chemotherapy strategy. Controlled pressure activates the mechanosensitive ion channel Piezo1 in bladder cancer, triggering a calcium ion cascade that transiently and reversibly amplifies membrane permeability to chemotherapeutics.
Minghai Ma, Xing Li, Minxuan Jing, Zezhong Yang, Jiale He, Jianpeng Li, Xiao Liang, Yunzhong Jiang, Rou Huang, Yuanquan Zhang, Yuanchun Pu, Jiawei Xiu, Yutong Chen, Kaibo Mi, Pu Zhang, Lei Wang, Jinhai Fan   +16 more
wiley   +1 more source

Modulation of protein fermentation does not affect fecal water toxicity: a randomized cross-over study in healthy subjects. [PDF]

PLoS ONE, 2012
Protein fermentation results in production of metabolites such as ammonia, amines and indolic, phenolic and sulfur-containing compounds. In vitro studies suggest that these metabolites might be toxic. However, human and animal studies do not consistently
Karen Windey, Vicky De Preter, Thierry Louat, Frans Schuit, Jean Herman, Greet Vansant, Kristin Verbeke   +6 more
doaj   +1 more source

Effects of NO synthase inhibitors on the synovial microcirculation in the mouse knee joint [PDF]

, 1999
Production of nitric oxide by the inducible NO synthase (iNOS) is known to be enhanced in chronic joint inflammation and osteoarthritis as well as aseptic loosening of joint prostheses.
Krombach, F., Messmer, K., Refior, H. J., Veihelmann, A.   +3 more
core   +1 more source

The Challenging P‐Alkylation of Aromatic Phosphorus Heterocycles and Follow‐Up Reactions

ChemistryEurope, EarlyView.
P‐alkylation of λ3σ2‐phosphinines is hindered by weak nucleophilicity and scarce synthetic access, previously requiring multistep routes or extreme electrophiles. A direct ambient‐condition method is reported using 3,5‐bis(trimethylsilyl)‐phosphinine/B(C6F5)3 with esters or iso(thio)cyanates to generate stable 1‐R‐phosphininium salts.
Samantha Frank, Ádám Horváth, Duy Nguyen, Moritz J. Ernst, Simon Steinhauer, Zoltán Benkő, Christian Müller   +6 more
wiley   +1 more source