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Isothiocyanates in medicine: A comprehensive review on phenylethyl-, allyl-, and benzyl-isothiocyanates

Pharmacological Research
In recent years, isothiocyanates (ITCs), bioactive compounds primarily derived from Brassicaceae vegetables and herbs, have gained significant attention within the biomedical field due to their versatile biological effects.
Barbara Wollenberg
exaly   +4 more sources

Current Methods for the Extraction and Analysis of Isothiocyanates and Indoles in Cruciferous Vegetables

Analytica, 2021
Cruciferous vegetables are characterized by the presence of sulfur-containing secondary plant metabolites known as glucosinolates (GLS). The consumption of cruciferous vegetables such as broccoli, cabbage, rocket salad, and cauliflower has been related ...
Sofia Karanikolopoulou, Panagiota-Kyriaki Revelou, Marinos Xagoraris, Maroula G. Kokotou, Violetta Constantinou-Kokotou   +4 more
doaj   +2 more sources

Dietary Isothiocyanates: Novel Insights into the Potential for Cancer Prevention and Therapy

International Journal of Molecular Sciences, 2023
Diet plays an important role in health. A high intake of plant chemicals such as glucosinolates/isothiocyanates can promote optimal health and decrease the risk of cancer.
Yong-ping Bao, Yu-Juan Shan
exaly   +2 more sources

Mechanisms Underlying Biological Effects of Cruciferous Glucosinolate-Derived Isothiocyanates/Indoles: A Focus on Metabolic Syndrome

Frontiers in Nutrition, 2020
An inverse correlation between vegetable consumption and the incidence of cancer has long been described. This protective effect is stronger when cruciferous vegetables are specifically consumed.
Montserrat Esteve, Montserrat Esteve
doaj   +2 more sources

Taste and flavour perceptions of glucosinolates, isothiocyanates, and related compounds [PDF]

Molecular Nutrition & Food Research, 2018
Brassicaceae plants are renowned for their taste, aroma and trigeminal characteristics; predominantly bitter taste, sulfurous aroma and pungency. Compounds responsible for these sensations include the glucosinolates (GSLs) and their hydrolysis products ...
Abe, Agerbirk, Agneta, Agrawal, Baik, Beaver, Behrens, Bell, Bell, Bell, Bell, Bell, Bennett, Bennett, Bonnema, Buck, Cartea, Cerny, Chen, Chin, Chin, Coogan, D'Antuono, D'Auria, Depree, Dinkova-Kostova, Doorn, Drewnowski, Elmore, Elmore, Engel, Fahey, Fenwick, Fenwick, Fowke, Frandsen, Frank, Freeman, Fukuda, Ghawi, Ghawi, Giacoppo, Halkier, Hanschen, Hanschen, Hansen, Hansen, Hasin, Hayes, Hayes, Holst, Hufnagel, Ishida, Jaeger, Jakubikova, Jin, Jirovetz, Jones, Jordt, Kato, Keller, Khataan, Kim, Kirimura, Kubec, Kuchernig, Levine, Lindsay, Ludikhuyze, Matusheski, Matusheski, McRae, Melchini, Mennella, Methven, Meyerhof, Nishimura, Okunade, Padilla, Palaniswamy, Palermo, Park, Parker, Pasini, Pence, Possenti, Prescott, Raffo, Rangkadilok, Reed, Ridgway, Sandell, Sansom, Sarkar, Schonhof, Shapiro, Shen, Siegmund, Steinmetz, Stoewsand, Sultana, Sultana, Suzuki, Swanston, Traka, Traka, Voutsina, Wills, Wold, Wu, Zabaras, Zhao   +111 more
core   +2 more sources

Isothiocyanates: a review [PDF]

Research Journal of Pharmacognosy, 2018
Isothiocyanates (ITCs) are naturally occurring molecules belonging to highly reactive organosulphur synthons, with the general structure R–N=C=S. The precursor molecule glucosinolate anions are hydrolyzed enzymatically (under the effect of myrosinase ...
Chandra Kala*, Syed Salman Ali, Nabeel Ahmad, Sadaf Jamal Gilani, Najam Ali Khan   +4 more
doaj   +2 more sources

The Role of Isothiocyanates as Cancer Chemo-Preventive, Chemo-Therapeutic and Anti-Melanoma Agents

Antioxidants, 2019
Many studies have shown evidence in support of the beneficial effects of phytochemicals in preventing chronic diseases, including cancer. Among such phytochemicals, sulphur-containing compounds (e.g., isothiocyanates (ITCs)) have raised scientific ...
Georgios Koutsidis, Dimitrios T Trafalis, Alexis Galanis   +2 more
exaly   +2 more sources

Isothiocyanates: An Overview of Their Antimicrobial Activity against Human Infections

Molecules, 2018
The use of plant-derived products as antimicrobial agents has been investigated in depth. Isothiocyanates (ITCs) are bioactive products resulting from enzymatic hydrolysis of glucosinolates (GLs), the most abundant secondary metabolites in the botanical ...
Letizia Romeo, Renato Iori, Patrick Rollin   +2 more
exaly   +2 more sources

Cruciferous Vegetables, Isothiocyanates, and Bladder Cancer Prevention

Molecular Nutrition and Food Research, 2018
Bladder cancer is a significant health burden due to its high prevalence, risk of mortality, morbidity, and high cost of medical care. Epidemiologic evidence suggests that diets rich in cruciferous vegetables, particularly broccoli, are associated with ...
Kenneth M Riedl, Steven K Clinton, Amir Mortazavi   +2 more
exaly   +2 more sources

Isothiocyanates: cholinesterase inhibiting, antioxidant, and anti-inflammatory activity

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Finding a new type of cholinesterase inhibitor that would overcome the brain availability and pharmacokinetic parameters or hepatotoxic liability has been a focus of investigations dealing with the treatment of Alzheimer’s disease.
Franko Burčul, Ivana Generalić Mekinić, Mila Radan   +2 more
exaly   +2 more sources