Results 131 to 140 of about 917,353 (421)

Residential Proximity to Major Roadways at Birth, DNA Methylation at Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva(Massachusetts, USA). [PDF]

, 2018
BackgroundEpigenetic variability is hypothesized as a regulatory pathway through which prenatal exposures may influence child development and health.ObjectiveWe sought to examine the associations of residential proximity to roadways at birth and ...
Agha, Golareh, Baccarelli, Andrea A, Cardenas, Andres, Coull, Brent A, de Kluizenaar, Yvonne, DeMeo, Dawn L, den Dekker, Martijn, Duijts, Liesbeth, Felix, Janine F, Gibson, Heike, Gilman, Matthew W, Gold, Diane R, Harris, Maria H, Hivert, Marie-France, Jaddoe, Vincent W, Litonjua, Augusto A, Oken, Emily, Peng, Cheng, Rifas-Shiman, Sheryl L, Sagiv, Sharon K, Schwartz, Joel   +20 more
core   +1 more source

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]

, 2018
DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola, Ciccarone, Fabio, Tagliatesta, Stefano, Zampieri, Michele   +3 more
core   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Convolutional Neural Networks In Classifying Cancer Through DNA Methylation [PDF]

arXiv, 2018
DNA Methylation has been the most extensively studied epigenetic mark. Usually a change in the genotype, DNA sequence, leads to a change in the phenotype, observable characteristics of the individual. But DNA methylation, which happens in the context of CpG (cytosine and guanine bases linked by phosphate backbone) dinucleotides, does not lead to a ...
arxiv  

A Hybrid HMM Approach for the Dynamics of DNA Methylation [PDF]

arXiv, 2019
The understanding of mechanisms that control epigenetic changes is an important research area in modern functional biology. Epigenetic modifications such as DNA methylation are in general very stable over many cell divisions. DNA methylation can however be subject to specific and fast changes over a short time scale even in non-dividing (i.e.
arxiv  

Promoter methylation analysis of WNT/β-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal cancer [PDF]

, 2014
Background: Aberrant DNA methylation as the most important reason making epigenetic silencing of genes is a main mechanism of gene inactivation in patients with colorectal cancer.
Alizadeh-Navaei, R., Azadeh, H., Farazmandfar, T., Samaei, N.M., Yazdani, Y.   +4 more
core   +1 more source

MethSurv: a web tool to perform multivariable survival analysis using DNA methylation data.

Epigenomics, 2018
AIM To develop a web tool for survival analysis based on CpG methylation patterns. MATERIALS & METHODS We utilized methylome data from 'The Cancer Genome Atlas' and used the Cox proportional-hazards model to develop an interactive web interface for ...
Vijayachitra Modhukur, Tatjana Iljasenko, Tauno Metsalu, Kaie Lokk, T. Laisk-Podar, J. Vilo   +5 more
semanticscholar   +1 more source

Epigenome‐wide association study, meta‐analysis, and multiscore profiling of whole blood in Parkinson's disease

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives An increasing body of evidence indicates altered DNA methylation in Parkinson's disease, yet the reproducibility and utility of such methylation changes are largely unexplored. We aimed to further elucidate the role of dysregulated DNA methylation in Parkinson's disease and to evaluate the biomarker potential of methylation‐based ...
Ingeborg Haugesag Lie, Manuela M. X. Tan, Maren Stolp Andersen, Mathias Toft, Lasse Pihlstrøm   +4 more
wiley   +1 more source

Methylation status of the SOCS 1 and JUNB genes in chronic myeloid leukemia patients Padrão de metilação dos genes SOCS 1 e JUNB em pacientes com leucemia mieloide crônica

Revista Brasileira de Hematologia e Hemoterapia, 2009
Alterations in the methylation status of genes may contribute to the progression of Chronic Myeloid Leukemia (CML). In this study, the methylation status in exon2 of SOCS- 1 and promoter regions of both SOCS- 1 and JUNB were evaluated in CML patients ...
Márcia Cristina R. Pena, Maria Inês M. C. Pardini, Virgilio A. R. Colturato, Nídia A. Pinheiro   +3 more
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