Results 171 to 180 of about 557,393 (318)

A Virus‐Inducible E3–RLCK–MADS Module Coordinates Suppression of Plant Immunity and Fertility in Rice

Advanced Science, EarlyView.
ABSTRACT Viruses often hijack host developmental programs to promote infection, but the mechanistic links between reproductive regulation and antiviral immunity remain incompletely understood. Here, we identify a virus‐triggered hierarchical degradation cascade that links antiviral immunity and fertility regulation in rice. We show that the rice grassy
Yuansheng Wu, Fengling Wu, Shiting Huang, Denglu Yang, Xin Lei, Xue Zhang, Na Liu, Peng Gan, Chuan Li, Jie Zhang, Ming Wu, Qingxiao Jia, Shanshan Zhao, Jianguo Wu   +13 more
wiley   +1 more source

Clinical Risk Stratification and Modifiable Risk Factors for Hepatitis B Virus-Related Follicular Lymphoma

ImmunoTargets and Therapy
Yuwei Deng,1 Zhenyuan Jia,1 Huilai Zhang,2 Xiaosan Zhang,3 Lihong Liu,4 Xianhuo Wang,2 Hongtao Song,5 Zirong Zhang,6 Caili Liu,6 Qingyuan Zhang,1 Jianli Ma7 1Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang,
Deng Y, Jia Z, Zhang H, Zhang X, Liu L, Wang X, Song H, Zhang Z, Liu C, Zhang Q, Ma J   +10 more
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Haplotype-resolved DNA methylation at the <i>APOE</i> locus identifies allele-specific epigenetic signatures relevant to Alzheimer's disease risk. [PDF]

NPJ Dement
Genner RM, Meredith M, Daida K, Moller A, Weller C, Ayuketah A, Jerez PA, Akeson S, Malik L, Baker B, Kouam C, Paquette K, Catching A, Bromberek S, Hu F, Reed X, Marenco S, Auluck P, Mandal A, Paten B, Gibbs JR, Jain M, Cookson MR, Singleton AB, Nalls M, Blauwendraat C, Billingsley KJ.   +26 more
europepmc   +1 more source

G6PC Downregulation Promotes Renal Calcium Oxalate Stone Formation via Lactate‐Induced SNAIL1 K206 Lactylation and Epithelial‐Mesenchymal Transition

Advanced Science, EarlyView.
In renal calcium oxalate stone formation, G6PC downregulation leads to lactate accumulation. This lactate mediates CBP/p300‐dependent lactylation of SNAIL1 at K206, promoting its nuclear translocation. Nuclear SNAIL1 activates the TGF‐β/SMAD3 pathway, driving epithelial‐mesenchymal transition and fibrosis, which ultimately facilitates crystal ...
Kai Liu, Boming Zhang, Ruixin Fan, Chen Duan, Yangjun Zhang, Huahui Wu, Xiangyang Yao, Xiongmin Mao, Bo Li, Youmiao Zeng, Zhenzhen Xu, Yang Wang, Mengcheng Luo, Xinyu Xu, Ninghan Feng, Heng Li, Hua Xu   +16 more
wiley   +1 more source

A novel m7G RNA methylation-related signature associated with MAPK signaling pathways in acute ischemic stroke. [PDF]

PLoS One
Gong WG, Lou JW, Yin S, Yu FP, Wu W.
europepmc   +1 more source

Targeting methylation [PDF]

Nature Reviews Nephrology, 2018
openaire   +2 more sources

Heterojunction‐Engineered Mass Spectrometry Platform for Deciphering Serum Metabolic Fingerprints in Diagnosis of Respiratory Diseases

Advanced Science, EarlyView.
Hollow Co3O4/TiO2 heterojunctions are engineered for high‐throughput laser desorption/ionization mass spectrometry. The built‐in electric field drives efficient charge separation and photothermal conversion, while the hierarchical mesoporous network enables robust salt and protein tolerance.
Junyu Chen, Chaoqi Wang, Xi Yu, Yuming Jiang, Yijiao Qu, Huihui Fu, Yuyin Bu, Xiaoyong Zhang, Zongxiu Nie   +8 more
wiley   +1 more source

Methylation plus alpha-fetoprotein blood test for early detection of HCC in at-risk populations. [PDF]

Hepatol Commun
Parikh ND, Liu CC, DeMaio M, Yeh AH, Stackpole ML, Li S, Agopian VG, Li W, Zhou XJ, Ni X, Lok AS, Han SB.   +11 more
europepmc   +1 more source

Master Regulator SMC1A, Stabilized by N6‐Methyladenosine Reader IGF2BP1, Promotes HCC Progression Through Facilitating Enhancer–Promoter Interaction of Nestin

Advanced Science, EarlyView.
IGF2BP1‐mediated m6A stabilization sustains SMC1A expression, enabling cohesin‐associated chromatin regulation of Nestin in hepatocellular carcinoma. This work reveals an epitranscriptomic‐chromatin‐cytoskeletal regulatory axis linked to malignant phenotypes and identifies SMC1A as a biologically relevant vulnerability in HCC.
Zhenxiang Peng, Diguang Wen, Lu Zeng, Lin Lv, Shengtao Liao, Wenguang Zhang, Zhechuan Mei, Chuanfei Li   +7 more
wiley   +1 more source

Association Between Proteasome 26S Subunit, Non-ATPase 3 Methylation and Insulin &beta; Cell Apoptosis in Type 2 Diabetic Mellitus

Diabetes, Metabolic Syndrome and Obesity
Guiping Huang,1,2,&ast; Guodong He,1,2,&ast; Shaoxian Chen,1 Liping Mai1,2 1Medical Research Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, People’s Republic of ...
Huang G, He G, Chen S, Mai L
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