Results 211 to 220 of about 881,260 (340)

DNA methylation and prediction of biological age. [PDF]

Front Mol Biosci
Chen Y, Cheng X, Ji S.
europepmc   +1 more source

Methylation of the chromatin modifier KMT2D by SMYD2 contributes to therapeutic response in hormone-dependent breast cancer

Ryan Blawski, Bujamin Vokshi, Xinyu Guo, Srushti Kittane, Mirna Sallaku, Wanlu Chen, Martina Gjyzari, Tony Cheung, Yuhan Zhang, Christopher E. Simpkins, Weiqiang Zhou, Amanda Kulick, Peihua Zhao, Meihan Wei, Pranavkrishna Shivashankar, Tatiana Prioleau, Pedram Razavi, Richard P. Koche, Vito W. Rebecca, Elisa de Stanchina, Pau Castel, Ho Man Chan, Maurizio Scaltriti, Emiliano Cocco, Hongkai Ji, Minkui Luo, Eneda Toska   +26 more
openalex   +1 more source

Genome-wide profiling of multiple histone methylations in olfactory cells: further implications for cellular susceptibility to oxidative stress in schizophrenia [PDF]

, 2012
Shin‐ichi Kano, Carlo Colantuoni, Fang-Xu Han, Zhifeng Zhou, Qiaoping Yuan, A.R.M. Wilson, Yoichiro Takayanagi, Y Lee, Judith L. Rapoport, William W. Eaton, Nicola G. Cascella, Hongkai Ji, David Goldman, Akira Sawa   +13 more
openalex   +1 more source

A Self‐Organized Liquid Reaction Container for Cellular Memory

Advanced Science, EarlyView.
How cells restore epigenetic information lost during replication is not known. This work proposes a mechanism based on the formation of biomolecular condensates. These condensates are induced by the chromosome itself and serve as reaction vessels for reconstructing missing epigenetic markers.
Sukanta Mukherjee, Enrico Skoruppa, Holger Merlitz, Jens‐Uwe Sommer, Helmut Schiessel   +4 more
wiley   +1 more source

Association of Arsenic Exposure with Whole Blood DNA Methylation: An Epigenome-Wide Study of Bangladeshi Adults [PDF]

, 2019
Kathryn Demanelis, Maria Argos, Tong Lin, Justin Shinkle, Mekala Sabarinathan, Muhammad Rakibuz‐Zaman, Golam Sarwar, Hasan Shahriar, Tariqul Islam, Mahfuzar Rahman, Mohammad Yunus, Joseph H. Graziano, Karin Bröberg, Karin Engström, Farzana Jasmine, Habibul Ahsan, Brandon L. Pierce   +16 more
openalex   +1 more source

PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders

Advanced Science, EarlyView.
This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang, Renjie Hu, Yanxi Chai, Ping He, Sanduo Li, Lisha Zhao, Wenbin Zhao, Lu Zhang, Li Qin, Ran Li, Xiaoli Hou, Qinghua Sun, Cuiqing Liu   +12 more
wiley   +1 more source

Integrative Epigenomic and Transcriptomic Profiling Define Malignancy- and Cluster-Specific Signatures in Pheochromocytomas and Paragangliomas. [PDF]

Cells
Tabebi M, Łysiak M, Gimm O, Söderkvist P.   +3 more
europepmc   +1 more source

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

Advanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia, Hongru Wang, Yu Dong, Zitong Yang, Yiyang Zhou, Zhinan Xia, Qinchen Li, Liangliang Ren, Yichun Zheng, Junliang Yan, Dongmei Ma, Zhi Chen, Xingang Cui, Guixin Zhu, Cheng Zhang   +14 more
wiley   +1 more source

Connecting Epigenetic and Genetic Diversity of LTR Retrotransposons in Sunflower (<i>Helianthus annuus</i> L.) and <i>Arabidopsis thaliana</i> L. [PDF]

Plants (Basel)
Tiurin K, Kazancev M, Merkulov P, Demurin Y, Soloviev A, Kirov I.   +5 more
europepmc   +1 more source

Histone H1 Limits DNA Methylation in Neurospora crassa [PDF]

, 2016
Michael Seymour, Lexiang Ji, Alex M. Santos, Masayuki Kamei, Takahiko Sasaki, Evelina Y. Basenko, Robert J. Schmitz, Xiaoyu Zhang, Zachary Lewis   +8 more
openalex   +1 more source