Results 281 to 290 of about 1,069,555 (390)

Association of DRD4 promoter-associated methylation with mild cognitive impairment in Han and Uygur populations. [PDF]

Eur J Med Res
Xu C, Liu G, Ji H, Yao Q, Cui W, Xu S, Zhou X, Yu J, Wang Q.   +8 more
europepmc   +1 more source

5‐Hydroxymethylcytosine Dynamics Reveals Coordinated Reprogramming of Parental Genomes and X Chromosome Dosage Balance in Mouse SCNT Embryos

Advanced Science, EarlyView.
Genome‐wide, high‐resolution profiling of hydroxymethylation in mouse SCNT embryos reveals a transient, allele‐symmetric 5hmC reprogramming pattern distinct from natural embryos, with X‐chromosomes and imprinting control regions resistant to proper remodeling.
Zeming Xiang, Rui Yan, Jing Guo, Mengyao Wang, Xin Cheng, Fan Zhang, Tianzi Guo, Xin Long, Fan Guo, Dan Liang   +9 more
wiley   +1 more source

Diagnostic potential of WNT signaling gene methylation in pulmonary tuberculosis. [PDF]

Front Immunol
Wang H, Wang CC, Huang Q, Xiao Y, Han Y, Xie L, Liu Y, Xiong YJ.   +7 more
europepmc   +1 more source

Intrinsic MicroRNA‐10a Restricts Regulatory T Cell Suppressive Function and Intestinal Repair by Coordinating Transcriptional, Metabolic, and Epithelial Repair Pathways

Advanced Science, EarlyView.
This study identifies microRNA‐10a (miR‐10a) as a key brake on regulatory T cell (Treg) suppressive function and intestinal repair. By targeting Blimp‐1, Uqcrq, and amphiregulin, miR‐10a restrains transcriptional, metabolic, and epithelial programs essential for Treg activity.
Wenjing Yang, Tianming Yu, Hui Yang, Suxia Yao, Ruihua Ma, Elizabeth M Steinert, Karen M Ridge, Weiguo Cui, Navdeep S Chandel, Yingzi Cong   +9 more
wiley   +1 more source

MethPy: a new software for analyzing non-CpG methylation after bisulfite assay and Sanger sequencing. [PDF]

Sci Rep
Roiati M, Borges LDF, Cattani A, Lucarelli M, Fuso A.   +4 more
europepmc   +1 more source

Increased DNA methylation contributes to the early ripening of pear fruits during domestication and improvement [PDF]

Bobo Song, Jinshan Yu, Xiaolong Li, Jiaming Li, Jing Fan, Hainan Liu, Weilin Wei, Lingchao Zhang, Kai‐Di Gu, Dongliang Liu, Kejiao Zhao, Jun Wu   +11 more
openalex   +1 more source

Two Novel S‐methyltransferases Confer Dimethylsulfide Production in Actinomycetota

Advanced Science, EarlyView.
This study identifies two novel S‐adenosine‐methionine‐dependent methyltransferases, MddM1 and MddM2, in actinomycetes from the Mariana Trench. These enzymes can convert toxic hydrogen sulfide (H2S) and methanethiol (MeSH) into dimethylsulfide (DMS), serving as a cellular detoxification and oxidative stress response.
Ruihong Guo, Zihua Guo, Yi Zhou, Yunhui Zhang, Haojin Cheng, Rebecca Devine, Chuang Sun, Ronghua Liu, Yanfen Zheng, Andrew J. Gates, Jonathan D. Todd, Xiao‐Hua Zhang   +11 more
wiley   +1 more source

Association of blood-based DNA methylation of lncRNAs with Alzheimer's disease diagnosis. [PDF]

Clin Epigenetics
Tian G, Zheng D, Zhang N, Deng W, Xu J, Huang C, Chen Q, Hu S, Xin L, Wang H, Wang B, Li K, Xu D.   +12 more
europepmc   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

DNA methylation-driven gene-based drug response prediction model for liver cancer: The critical role of GLS. [PDF]

PLoS One
Zheng S, Yu X, Wang X, Ma Y, Han Y, Zhang J, Wu W, Sun C, He L.   +8 more
europepmc   +1 more source