Results 301 to 310 of about 1,069,555 (390)

Differential DNA methylation in infants with IgE- and non-IgE-mediated cow's milk allergy and its association with acquired tolerance. [PDF]

Front Immunol
López-Gómez R, Gil-Martínez M, Ladrón-Guevara A, Rodrigo-Muñoz JM, Lorente-Sorolla C, Rodríguez-González D, García de Castro Z, Guillén-Sánchez G, Serrano-Santiago A, Mirasierra-Pérez R, Cañas JA, Del Río Camacho G, Del Pozo V.   +12 more
europepmc   +1 more source

Lactylation Enhances the Activity of Lactate Dehydrogenase A and Promotes the Chemoresistance to Cisplatin Through Facilitating DNA Nonhomologous End Junction in Lung Adenocarcinoma

Advanced Science, EarlyView.
Lactylation, linked to glycolysis, is poorly understood in regulation. It is found that LDHA is lactylated at Lys81/Lys318 by AARS1, boosting its activity and cellular lactylation via positive feedback in LUAD. Lactylation regulates NHEJ‐related proteins; their delactylation impairs NHEJ and increases cisplatin sensitivity, offering anticancer insights.
Jizhuo Li, Wenze Xun, Xijie Wang, Ruiguang Luo, Qifan Hu, Zhaocai Zhou, Jian Yuan, Yanan Wang, Xiaorui Wan, Tao Zhao, Tianyu Han, Jian‐Bin Wang   +11 more
wiley   +1 more source

DNA N6-methyladenine modifications of Acidithiobacillus ferrooxidans response to copper stress. [PDF]

PLoS One
Liu J, Qiu H, Tan D, Zhang Y, Yang Y.
europepmc   +1 more source

Dual DNA Methylation Patterns in the CNS Reveal Developmentally Poised Chromatin and Monoallelic Expression of Critical Genes

, 2010
Jinhui Wang, Zuzana Valo, Chauncey W. Bowers, David Smith, Zheng Liu, Judith Singer–Sam   +5 more
openalex   +2 more sources

Allelic Variation in Maize Malate Dehydrogenase 7 Shapes Promoter Methylation and Banded Leaf and Sheath Blight Resistance

Advanced Science, EarlyView.
In this study maize chloroplastic malate dehydrogenase7 (ZmMDH7), is identified as a Rhizoctonia solani resistance gene in maize. ZmMDH7 is regulated by transcription factor ZmWRKY44 via pathogens challenge to elevate mitochondrial ROS and SA signaling pathway.
Luyang Wei, Junbin Chen, Chuang Liu, DanDan Liu, Meida Du, Shengfeng He, Wenyu Cheng, Vijai Bhadauria, You‐Liang Peng, Wangsheng Zhu   +9 more
wiley   +1 more source

Mass Spectrometry for Lysine Methylation: Principles, Progress, and Prospects. [PDF]

Biomedicines
Cumming MG, Biggar KK.
europepmc   +1 more source

Proteogenomic Characterization Reveals Metabolic Vulnerabilities and Aberrant Phosphorylation in Colorectal Metastasis to Liver

Advanced Science, EarlyView.
This study provides a multi‐omics landscape of treatment‐naïve colorectal liver metastasis and reveals dysregulated molecules and cellular pathways. SHMT1 and NDRG1 Ser330 phosphorylation are demonstrated to display crucial roles in tumorigenesis and liver metastasis. Two proteomics subtypes (metabolism and RNA function) with distinct clinical outcomes
Wensi Zhao, Lei Zhao, Yannan Lian, Zhiwei Liu, Yaqi Li, Xuege Wang, Mingya Zhang, Ni Li, Jingli Guo, Danqing Shen, Shaobo Mo, Jiahao Li, Linhui Zhai, Jiahui Ni, Sangkyu Lee, Bin Liu, Jing Li, Fei Wang, Junjie Peng, Jun Qin, Minjia Tan   +20 more
wiley   +1 more source

Longitudinal Analysis of Estrogen Receptor Gene Methylation, Estradiol, and Depressive Symptoms During the Perinatal Period. [PDF]

Mol Neurobiol
Zorzini G, Johann A, Dukic J, Gardini E, Ehlert U.   +4 more
europepmc   +1 more source

Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders

Advanced Science, EarlyView.
This review systemically summarizes the structure, expression, regulatory networks, and isoform‐specific signaling of GSPT1 in cancers. According to the integration of GSPT1 targeted therapies, current challenges of GSPT1 targeted therapies are further analyzed, and provide therapeutic opportunities for the application of GSPT1 degraders in precision ...
Qiqi Lin, Wenjing Liu, Wenjia Lu, Monong Zhao, Lin Cao, Zhiyu Li, Jubo Wang, Xi Xu, Hongxi Wu   +8 more
wiley   +1 more source

EnsembleAge clock: a reliable and robust epigenetic age clock service reveals epigenetic age acceleration in opioid-overdosed brains. [PDF]

BMC Genomics
Anand A, Agarwal Y, Gupta T, Lin J, Ghemrawi M, Gerhard GS, Lee H.   +6 more
europepmc   +1 more source