Results 151 to 160 of about 9,356 (215)

Multi-omics reveals the mechanism of vagus nerve stimulation in the treatment of chronic congestive heart failure. [PDF]

Sci Rep
Hu Y, Dai S, Chen L, Ma X, Li H, Lu Y, Li C, Chen X, Li H, Lu Y, Huang Y, Zhao L, Hua B, Zhao L.   +13 more
europepmc   +1 more source

OMA1 protects from liver injury and tumorigenesis during aging by controlling hepatic immunogenicity. [PDF]

EMBO J
Martí-Mateos Y, Muñoz-Hernández MDM, Gómez de Las Heras MM, Escrig-Larena JI, Cabrera-Alarcón JL, Acín-Pérez R, Calvo E, Jaroszewicz SN, de Prado-Rivas L, Martínez-Jiménez ER, De Andrés-Laguillo M, García-Domínguez E, Gómez-Cabrera MC, Viña J, Benedito R, Efeyan A, Vázquez J, Mittelbrunn M, Jiménez-Gómez MC, Enríquez JA.   +19 more
europepmc   +1 more source

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Fungal oxidation of 3-methylcholanthrene: Formation of proximate carcinogenic metabolites of 3-methylcholanthrene

Chemico-Biological Interactions, 1982
The filamentous fungus, Cunninghamella elegans, was found to metabolize the potent carcinogen, 3-methylcholanthrene (3-MC) to 1-hydroxy-3-MC, 2-hydroxy-3-MC, 1-keto-3-MC, 2-keto-3-MC and trans-9,10-dihydrodiols of 1-hydroxy-3-MC. In addition several unidentified derivatives of 3-MC were found.
D T Gibson, C E Cerniglia
exaly   +3 more sources

The identification of 3-methylcholanthrene-9,10-dihydrodiol as an intermediate in the binding of 3-methylcholanthrene to DNA in cells in culture

Chemico-Biological Interactions, 1978
Two metabolites of 3-methylcholanthrene (3MC), previously shown to be precursors of the DNA-bound form of 3MC observed in embryo cells in culture, were prepared from 3MC by microsomal metabolism and isolated by high pressure liquid chromatography (HPLC).
P Brookes, M R Osborne, M R Osborne
exaly   +3 more sources

Karyology of Rhabdomyosarcomas Induced with 3-Methylcholanthrene

Tumori Journal, 1972
This work aims to find out how a neoplastic condition affects the chromosome set of the rat. Malignant tumors were induced by 3-methylcholanthrene in adult rats. The karyologic examination of 3 sarcomas (S1, S2, S3) showed that: in S1 65% of the metaphases are hypotetraploid; in S2 75% of the metaphases are roughly diploid and only 25 % are ...
Marisa Basso
openaire   +3 more sources

Uptake of methylcholanthrene in the rat pancreas

The American Journal of Digestive Diseases, 1974
Epidemiologic studies show an increase in the incidence of pancreatic carcinoma and suggest that this increase may result, at least in part, from increased exposure to chemical carcinogens. Little information is available concerning the uptake of such agents or their effects on the pancreas.
O, Black, P D, Webster
openaire   +2 more sources

Metabolism of Radioactive Methylcholanthrene in the Rat

Nature, 1963
IT has long been known that the administration of methylcholanthrene by the alimentary tract can produce mammary tumours in certain strains of mice and rats. Prohaska, Brunschwig and Wilson1 first reported four mammary tumours in 15 mice fed 1.2 mg methylcholanthrene three times weekly for up to six weeks.
A L, FOODALL, M H, McINTYRE, J S, KENNEDY   +2 more
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A Test for Mutagenicity of Methylcholanthrene

Nature, 1948
RECENT results by Strong1,2 and by Carr3 on mice, and by Demerec4 on Drosophila, have focused interest on a possible connexion between mutagenicity and carcinogenicity, which in the past has often been claimed on theoretical grounds. While Auerbach5 failed to produce mutations by injection of 1 : 2 : 5 : 6 dibenzanthracene into Drosophila, Demerec ...
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Synthesis of 3-methylcholanthrene

Tetrahedron Letters, 1981
Abstract A novel synthesis of 3-methylcholanthrene is described which is operationally sipmler than the method in current use and is potentially applicable to the synthesis ofa wide range of other polycyclic hydrocarbons and their cracinogenic metabolites.
Stephen A. Jacobs, Ronald G. Harvey
openaire   +1 more source

Methylcholanthrene-Induced Thyroiditis

Archives of Environmental Health: An International Journal, 1969
Five unrelated strains of inbred female rats were given 0.033% 3-methylcholanthrene in the diet for 12 weeks. Buffalo-strain rats were the only animals that developed chronic thyroiditis. Fischer, ACI, Marshall, and Osborne Mendel strain rats did not. The protein bound iodine values in the experimental animals did not differ significantly from those in
E L, Glover, M D, Reuber, E F, Godfrey
openaire   +2 more sources