Results 21 to 30 of about 13,801 (241)

Safety and efficacy of methyldopa and labetalol in controlling blood pressure in hypertensive disorders of pregnancy

, 2017
Background: Hypertensive disorders represent the most common medical complication of pregnancy, with a reported incidence of 6-10% and accounts for 15% of maternal mortality.
Mary Rohini Pentareddy, D. Shailendra, G. Prasuna, Y. Subbaratnam, D. Naresh, Rajshekar Katta   +5 more
semanticscholar   +3 more sources

Novel Strongly Basic Molecularly Imprinted Solid-Phase Extraction Sorbent for Simultaneous Determination of Catecholamines and Their Metabolites in Urine. [PDF]

J Sep Sci
ABSTRACT Catecholamines are important hormones and neuromediators in the human body. Simultaneous determination of both catecholamines and catecholamine metabolites in bodily fluids can help accurately diagnose dangerous health conditions like adrenal tumors.
Šilaks A, Podjava A, Bernāte L, Grebnevs V, Maciej A.   +4 more
europepmc   +2 more sources

Resolution of Preeclampsia After Single Selective Termination in Twins: A Case Series and Literature Review. [PDF]

Clin Case Rep
ABSTRACT Preeclampsia significantly contributes to maternal and perinatal morbidity and mortality, with twin pregnancies increasing this risk. Severe preeclampsia often requires pregnancy termination to protect maternal health. We report two cases of IVF‐conceived twin pregnancies complicated by early preeclampsia. The first case involved a 34 year‐old
Golshahi F, Rahimi Sharbaf F, Saedi N, Shirazi M, Sahebdel B, Golshahi J, Ebrahimi M, Mollaalipour Amiri M, Hamidi Madani Z.   +8 more
europepmc   +2 more sources

Risk of major congenital malformations associated with first-trimester antihypertensives, including amlodipine and methyldopa: A large claims database study 2010-2019.

Pregnancy Hypertension, 2023
OBJECTIVES To evaluate the major congenital malformation (MCM) risk of first-trimester antihypertensive exposure, specifically of amlodipine and methyldopa. STUDY DESIGN A large administrative claims database was used.
Tomofumi Ishikawa, H. Nishigori, Manabu Akazawa, K. Miyakoda, A. Noda, M. Ishikuro, H. Metoki, N. Iwama, Masatoshi Saito, J. Sugawara, H. Kawame, N. Yaegashi, S. Kuriyama, N. Mano, T. Obara   +14 more
semanticscholar   +1 more source

Pharmacokinetics of the most commonly used antihypertensive drugs throughout pregnancy methyldopa, labetalol, and nifedipine: a systematic review

European Journal of Clinical Pharmacology, 2022
Antihypertensive drugs are among the most prescribed drugs during pregnancy. Methyldopa, labetalol, and nifedipine have been perceived safe to use during pregnancy and are therefore recommended in international guidelines for treatment of hypertension ...
Dylan van de Vusse, P. Mian, S. Schoenmakers, R. Flint, W. Visser, K. Allegaert, J. Versmissen   +6 more
semanticscholar   +1 more source

Synthesis of Methyldopa–Tin Complexes and Their Applicability as Photostabilizers for the Protection of Polyvinyl Chloride against Photolysis

Polymers, 2022
Polyvinyl chloride (PVC) is a ubiquitous thermoplastic that is produced on an enormous industrial scale to meet growing global demand. PVC has many favorable properties and is used in various applications.
Noor Naoom, E. Yousif, D. Ahmed, B. Kariuki, Gamal A. El‐Hiti   +4 more
semanticscholar   +1 more source

Development and validation of a fast HPLC method for methyldopa enantiomers using superficially porous particle based macrocyclic glycopeptide stationary phase

, 2021
Methyldopa is a centrally acting antihypertensive agent, whose pharmacological activity is attributed to the S-α-methyldopa enantiomer. The assessment of enantiomeric purity is an essential quality control test for chiral drugs, as the presence of ...
M. S. S. Gonçalves, D. Armstrong, L. Cabral, Eduardo Costa Pinto, V. P. Sousa   +4 more
semanticscholar   +1 more source

Physical properties and biological activity of methyldopa drug carrier cellulose derivatives. Theoretical study

Egyptian Journal of Chemistry, 2021
The complete computational study of the methyldopa drug and its derivatives prodrug 1-4(methyldopa-cellulose (Ce), methyldopa-carboxymethyl cellulose(CMC), methyldopa-maleic anhydride cellulose (MAC)and methyldopa-hydroxypropyl cellulose(HPC)) was ...
M. Merza, F. Hussein, R. Al-Ani
semanticscholar   +1 more source

Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders. [PDF]

, 2008
Antihypertensive drugs are believed to lower blood pressure in pre-eclampsia by direct or central vasodilatory mechanisms. However, they could also act by decreasing production of anti-angiogenic proteins involved in the pathophysiology of hypertension ...
Muttukrishna Shanthi, Muttukrishna, S, Khalil Asma, Khalil, A, Jauniaux, E, Harrington, K, Jauniaux Eric, Kevin Harrington, Harrington Kevin, Shanthi Muttukrishna, Asma Khalil, Eric Jauniaux   +11 more
core   +1 more source

Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomised controlled trial

The Lancet, 2019
Summary Background Hypertension is the most common medical disorder in pregnancy, complicating one in ten pregnancies. Treatment of severely increased blood pressure is widely recommended to reduce the risk for maternal complications.
T. Easterling, S. Mundle, H. Bracken, Seema Parvekar, Sulabha Mool, L. Magee, P. von Dadelszen, T. Shochet, B. Winikoff   +8 more
semanticscholar   +1 more source