Results 41 to 50 of about 107,807 (121)

Moderately elevated plasma homocysteine, methylenetetrahydrofolate reductase genotype, and risk for stroke, vascular dementia, and Alzheimer disease in Northern Ireland

, 2002
Elevated plasma homocysteine level has been associated with increased risk for cardiovascular and cerebrovascular disease. Variation in the levels of this amino acid has been shown to be due to nutritional status and methylenetetrahydrofolate reductase ...
Dynan, Kevin B, Patterson, Christopher C, McIlroy, Stephen P, Passmore, A Peter, Lawson, John T   +4 more
core   +1 more source

Structural and mechanistic investigations of methylenetetrahydrofolate reductase and their functional implications.

, 1992
Methylenetetrahydrofolate reductase catalyzes the reduction of N$\\sp{5,10}$-methylenetetrahydrofolate to N$\\sp5$-methyltetrahydrofolate. Reducing equivalents are provided by NADPH and transferred through a noncovalently bound cofactor flavin adenine ...
Sumner, James Sullivan
core   +3 more sources

Relation Between Folate Status, a Common Mutation in Methylenetetrahydrofolate Reductase, and Plasma Homocysteine Concentrations

, 2013
Methylenetetrahydrofolate reductase (MTHFR) synthesizes 5-methyltetrahydrofolate, the major carbon donor in remethylation of homocysteine to methionine.
Selhub, Jacob, Bostom, Andrew G., Williams, Roger R., Eckfeldt, John H., Ellison, R. Curtis, Rozen, Rima, Jacques, Paul. F., Rosenberg, Irwin H.   +7 more
core  

Infertility in 5,10-Methylenetetrahydrofolate Reductase (MTHFR)-Deficient Male Mice Is Partially Alleviated by Lifetime Dietary Betaine Supplementation

, 2013
Metabolism of folate is essential for proper cellular function. Within the folate pathway, methylenetetrahydrofolate reductase (MTHFR) reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a methyl donor for remethylation of homocysteine to
Kelly, Tamara L. J., Schwahn, Bernd C., Trasle, Jacquetta M., Rozen, Rima, Neaga, Oana R.   +4 more
core  

Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice

, 2008
Objective Folates provide one-carbon units for nucleotide synthesis and methylation reactions. A common polymorphism (677C -> T) in methylenetetrahydrofolate reductase (MTHFR) encodes an enzyme with reduced activity.
Leclerc, Daniel, ÇELTİKÇİ, BAŞAK, Lawrance, Andrea K., Friedman, Hana C., Peterson, Alan C., Melnyk, Stepan, Deng, Liyuan, Krupenko, Natalia I., Rozen, Rima, James, S. Jill, Krupenko, Sergey A.   +10 more
core   +1 more source

The Importance of Homozygous Polymorphisms of Methylenetetrahydrofolate Reductase Gene in Romanian Patients with Idiopathic Venous Thromboembolism

, 2013
Background: Methylenetetrahydrofolate reductase (MTHFR) polymorphisms have recently raised the interest as a possible thrombophilic factors. Aims: We aimed to assess the frequency of the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C ...
Cristina Hotoleanu, Radu Popp, Daniela Fodor, Adrian Trifa   +3 more
core   +1 more source

Identification of amino acid residues essential for enzyme activity of sheep liver 5,10-methylenetetrahydrofolate reductase

, 1986
Sheep liver 5, 10-methylenetetrahydrofolate reductase was subjected to specific chemical modification with phenylglyoxal, diethyl pyrocarbonate and N-bromosuccinimide.
Savithri, H. S., Varalakshmi, K., Rao, N. A.   +2 more
core   +2 more sources

Methylenetetrahydrofolate Reductase Polymorphism, Plasma Folate, Homocysteine, and Risk of Myocardial Infarction in US Physicians

, 2013
Hyperhomocysteinemia appears to be an independent risk factor for coronary disease. Elevated levels of plasma total homocysteine (tHCY) can result from genetic or nutrient-related disturbances in the transsulfuration or remethylation pathways for ...
Ma, Jing, Malinow, M. Rene, Willett, Walter C., Hennekens, Charles H., Frosst, Phylis, Stampfer, Meir J., Selhub, Jacob, Rozen, Rima, Horsford, Jonathan   +8 more
core  

Structural basis of S-adenosylmethionine-dependent allosteric transition from active to inactive states in methylenetetrahydrofolate reductase

Methylenetetrahydrofolate reductase (MTHFR) is a pivotal flavoprotein connecting the folate and methionine methyl cycles, catalyzing the conversion of methylenetetrahydrofolate to methyltetrahydrofolate.
Johnny Mendoza, Markos Koutmos, Kazuhiro Yamada   +2 more
core   +1 more source

Contribution of <i>MTHFR</i> C677T and A1298C Variants to Retinoblastoma Risk in Mexican Children. [PDF]

Genes (Basel)
Perez-Becerra JJ, Ramirez-Corona JA, Fernandez Sanchez D, Flores Leura FA, Brukman-Jimenez SA, Corona-Rivera A, Corona-Rivera JR, Gonzalez-Perez G, Calderon-Camacho GH, Pizano AMF, Leon JAM, Orozco-Vela M, Bobadilla-Morales L.   +12 more
europepmc   +1 more source