Results 91 to 100 of about 160 (142)

Cytostatischer Wirkungsmechanismus der Methylhydrazine

Experientia, 1964
Cytostatic active methylhydrazine derivatives split off formaldehyde after mild dehydrogenation with potassium hexacyanoferrate (III). It is suggested that the primary formedazomethines andN-hydroxymethylderivatives participate in cytostatic efficacy by their alkylating ability (aminomethylation).
G. Weitzel, F. Schneider, Anna-Maria Fretzdorff   +2 more
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ChemInform Abstract: ACYLIERUNGSRK. AN METHYLHYDRAZIN

Chemischer Informationsdienst. Organische Chemie, 1971
AbstractMethylhydrazin (I) reagiert mit Dimethyl‐ oder Diäthylcarbonat (II) in 15 bzw. 27%iger Ausbeute zu den 1‐Alkoxycarbony1‐1‐methylhydrazinen (III) und in 27 bzw. 39%iger Ausbeute zu den 1‐Methyl‐2‐alkoxycarbonylhydrazinen (IV), die sich durch fraktionierte Kristallisation trennen lassen.
G. ZINNER, U. GEBHARDT
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Reaction of pyrylium salts with methylhydrazine

Journal of the Chemical Society D: Chemical Communications, 1970
The reaction of (1; R = Ph or Me) with methyl-hydrazine leads to a variety of products, (2e), (3d), (3e), (5), (6a), and (7), depending on the selected pyrylium salt and reaction conditions.
Victor Snieckus, Gordon Kan
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Reaction of methylhydrazine with dimethyl chlorothiophosphate

Journal of the Chemical Society, Dalton Transactions, 1994
The reaction of 2 equivalents of methylhydrazine with 1 equivalent of (MeO)2P(S)Cl at 0 °C produced the phosphorus hydrazide (MeO)2P(S)NMeNH21 in good yield. However, at 25 °C a mixture of three products was obtained according to 1H and 31P NMR spectra. The pure individual components were separated by column chromatography.
Przemyslaw Lusiak, Prahlad R. Singh, Kattesh V. Katti   +2 more
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Ueber das Methylhydrazin

Justus Liebigs Annalen der Chemie, 1889
Von den Hydrazinen der Fettreihe sind bisher die Monoathyl-, Diathyl- und Dimethylverbindungen naher untersucht; dagegen ist die einfachste dieser Basen, das Methylhydrazin, noch nicht erhalten worden.
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Initial experiences with methylhydrazine, a new cytotoxic agent

Clinical Radiology, 1966
The authors present their results using methylhydrazine (‘Ro 4-6467’, ‘Natulan’) in the treatment of 40 patients with malignant disease. The progress of 29 patients could be adequately assessed. Remissions occurred frequently in patients with Hodgkin's disease and some solid tumours also showed a response.
T W, Backhouse, K, Sicher
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Analysis of the inversion splittings in methylhydrazine

Journal of Molecular Spectroscopy, 1989
Abstract Microwave spectral data on the inversion splittings in methylhydrazine have been analyzed by the use of a generalized internal-axis method developed by Hougen. Inversion tunneling parameters reproducing the observed splittings well have been determined through a least-squares analysis for the inner and outer conformations.
Nobukimi Ohashi, Norio Murase, Kaoru Yamanouchi, Masaaki Sugie, Harutoshi Takeo, Chi Matsumura, Kozo Kuchitsu   +6 more
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Methylhydrazine derivatives, a new class of cytotoxic agents

Experientia, 1963
Ausgehend von der Beobachtung, dass 1-Methyl-2-benzyl-hydrazin tumorhemmend wirkt, wurden durch systematische Variationen die fur diese Wirkung essentiellen Strukturmerkmale festgelegt. Aus einer grosseren Anzahl von Verbindungen wurden 1-Methyl-2-p-(isopropylcarbamoyl)benzyl-hydrazin-hydrochlorid und 1-Methyl-2-p-allophanoylbenzyl-hydrazin-hydrobromid
P, ZELLER, H, GUTMANN, B, HEGEDUS, A, KAISER, A, LANGEMANN, M, MULLER   +5 more
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Mutagen and Oncogen Study of Methylhydrazine

1976
Abstract : A three tier test was organized into a matrix of assays employing microbial cells, mammalian cells in culture, and in vivo experiments in rats and mice. Methylhydrazine (MH) was mutagenic for Salmonella typhimurium TA-1535 in suspension tests. Results from all other assays conducted as part of this evaluation were considered to be negative.
Dale W. Matheson, David Brusick
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Hydrazine, methylhydrazine and methylhydrazine sulfate carcinogenesis in swiss mice. failure of ammonium hydroxide to interfere in the development of tumors

International Journal of Cancer, 1972
AbstractSolutions of hydrazine as 0.001%, methylhydrazine as 0.01%, methylhydrazine sulfate as 0.001%, and ammonium hydroxide as 0.3, 0.2 and 0.1% were administered continuously in the drinking water of 5‐ and 6‐week‐old randomly bred Swiss mice for their entire lifetime.
openaire   +2 more sources