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Oxidative demethylation of N-methylhydrazines by rat liver microsomes

Archives of Biochemistry and Biophysics, 1969
Abstract Certain N -methylhydrazines were found to be oxidatively demethylated to yield formaldehyde by rat liver microsomal preparations. Substrates for the N -demethylase were found to be monomethylhydrazine, 1,1-dimethylhydrazine, 1,2-dimethylhydrazine, Procarbazine, and the azo derivative of Procarbazine.
Russell A Prough
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