Design, Synthesis, and Biological Studies of New Phenanthroindolizidine [PDF]
, 2010 The overall goals of this research were to design and synthesize novel phenanthroindolizidine and phenanthroquinolizidine analogs, study corresponding structure-activity relationships, and explore their potential mechanisms of action as a new class of ...
Yang, Xiaoming
core +2 more sources
Two‐Step Synthesis of Enantiomerically Pure Morphans from (R)‐Carvone
ChemMedChem, Volume 19, Issue 24, December 16, 2024.A two‐step procedure transformed the natural product (R)‐carvone into enantiomerically pure morphans allowing selective modifications at 2‐, 4‐ and 6/7‐position. Whereas affinity towards opioid receptors could not be detected, nanomolar σ1 affinity was found for indolomorphans and quinolinomorphans.
Giuliana Costanzo +5 more
wiley +1 more source
The hard start phenomena in hypergolic engines. Volume 1: Bibliography [PDF]
A bibliography of reports pertaining to the hard start phenomenon in attitude control rocket engines on Apollo spacecraft is presented. Some of the subjects discussed are; (1) combustion of hydrazine, (2) one dimensional theory of liquid fuel rocket ...
Miron, Y., Perlee, H. E.
core +1 more source
Synthesis and functionalization of a lactam-pyrazole molecular scaffold as a promising anticancer compound [PDF]
, 2015 The importance of pyrazole and lactam-based molecules in medical and pharmaceutical fields is underlined by the multitude of active ingredients on trade, such as Sildenafil or Apixaban, by Pfizer.
Bertuzzi, Giulio
core
Archiv der Pharmazie, Volume 357, Issue 10, October 2024.Novel phthalazine‐1,4‐dione acetylcholinesterase (AChE) inhibitors with exceptional activity against Alzheimer's disease were synthesized and evaluated. Three compounds, 8m, 8n, and 8p, demonstrated remarkable AChE inhibition similar to donepezil. Molecular docking and dynamic simulations confirmed stability and therapeutic potential as a significant ...
Demokrat Nuha +4 more
wiley +1 more source
Computing Network of Diseases and Pharmacological Entities through the Integration of Distributed Literature Mining and Ontology Mapping [PDF]
, 2011 The proliferation of -omics (such as, Genomics, Proteomics) and -ology (such as, System Biology, Cell Biology, Pharmacology) have spawned new frontiers of research in drug discovery and personalized medicine.
Faisal, Fazle Elahi
core +1 more source
Drug Consumption in Norway 2018-2022 - Data from Norwegian Drug Wholesales Statistics [PDF]
, 2023 Årets rapport Legemiddelforbruket i Norge omfatter tallmateriale og informasjon fra Grossistbasert legemiddelstatistikk for perioden 2018-2022. Denne rapporten har tidligere inneholdt data også fra Reseptregisteret (Norwegian Prescription Database; NorPD)
Bakken, Gry Vibeke +4 more
core
Bringing New Chemistry to Guanosine Hydrogels [PDF]
, 2020 Molecular self-assembly is a powerful method to construct functional materials such as supramolecular hydrogels. Hydrogels contain mostly water but show solid-like rheology. Nucleosides and nucleotides contain rich recognition information, which opens up
Xiao, Songjun
core +1 more source
Osteolathyrogenic effects and structure-activity analysis for a series of acid hydrazines [PDF]
, 1985 The osteolathyrogenic effects and structure-activity relationships (SAR) of a homologous series of hydrazines were examined using the Frog Embryo Teratogenesis Assay; Xenopus (FETAX).
Riggin, Geoffrey W.
core +1 more source
The oxidative demethylation of certain N-methylhydrazines by microsomal liver enzymes [PDF]
The presence in rat liver microsomes of an enzyme system which demethylates N-methylhydrazines and azo compounds to formaldehyde has been reported. Some of the compounds found to be substrates were monomethylhydrazine, N-isopropyl-α-(2-methylhydrazino ...
Wittkop, Judith Anne
core +1 more source