Homocysteine and methylmalonic acid in Phenylketonuria patients [PDF]
Genetics and Molecular Biology, 2023 Hyperhomocysteinemia and vitamin B12 deficiency have been reported in patients with phenylketonuria. In this study, total homocysteine (tHcy) and methylmalonic acid (MMA) levels were analyzed in samples from 25 phenylketonuria (PKU) patients. Comparisons
Giovana Regina Weber Hoss +7 more
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Methylmalonic acid levels in serum, exosomes, and urine and its association with cblC type methylmalonic acidemia-induced cognitive impairment [PDF]
Frontiers in Neurology, 2022 BackgroundThe cblC type methylmalonic acidemia is the most common methylmalonic acidemia (MMA) in China. The biochemical characteristics of this disease include elevated methylmalonic acid and homocysteine (HCY), increased propionylcarnitine (C3 ...
Shuqi Sun +4 more
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The utility of methylmalonic acid, methylcitrate acid, and homocysteine in dried blood spots for therapeutic monitoring of three inherited metabolic diseases [PDF]
Frontiers in NutritionBackgroudRoutine metabolic assessments for methylmalonic acidemia (MMA), propionic acidemia (PA), and homocysteinemia involve detecting metabolites in dried blood spots (DBS) and analyzing specific biomarkers in serum and urine.
Yi Liu +8 more
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Methylmalonic acid in aging and disease. [PDF]
Trends Endocrinol MetabMetabolic byproducts have conventionally been disregarded as waste products without functions. In this opinion article, we bring to light the multifaceted role of methylmalonic acid (MMA), a byproduct of the propionate metabolism pathway mostly commonly known as a clinical biomarker of vitamin B12 deficiency.
Tejero J, Lazure F, Gomes AP.
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Relationship between methylmalonic acid and cobalamin in uremia [PDF]
Kidney International, 2000 Relationship between methylmalonic acid and cobalamin in uremia.To evaluate the requirement for routine supplementation with vitamin B12 and to study the effect of a change from injection to oral B12 supplementation, we examined the relationship between cobalamin and methylmalonic acid in plasma from 67 patients on chronic hemodialysis, all in regular ...
L. Moelby +3 more
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Serum cobalamin and methylmalonic acid concentrations in juvenile dogs with parvoviral enteritis or other acute enteropathies [PDF]
Journal of Veterinary Internal Medicine, 2023 Background Low serum cobalamin concentrations have been associated with ileal malabsorption in dogs with chronic enteropathy. Increased serum methylmalonic acid (MMA) concentrations indicate cobalamin deficiency on a cellular level.
Michael Hung +4 more
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Antioxidant System Disturbances, Bioenergetic Disruption, and Glial Reactivity Induced by Methylmalonic Acid in the Developing Rat Brain [PDF]
NeurogliaBackground: Elevated levels of methylmalonic acid (MMA) are observed in the bodily fluids and tissues of patients with methylmalonic aciduria, a metabolic disorder characterized by manifestations such as vomiting, lethargy, muscle weakness, seizures, and
Cristiano Antonio Dalpizolo +9 more
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Association between methylmalonic acid and Alpha-Klotho in American adults: A cross-sectional study. [PDF]
PLoS OneBao R +6 more
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The Reaction of Methylmalonic Acid with Aldehydes
Nippon kagaku zassi, 1962 π-プチルアルデヒド,π-ヘプタアルデヒド,およびρ-ニトロベンズァルデヒドをメチルマロン酸とピリジンまたはトリェチルアミンの存在で反応させた。反応は脱炭酸のみをともない,α-メチル-β-オキシカルボン酸が生成された。このオキセ酸を85%硫酸中でラクトン化させてα-メチル-γ-カプロラクトンおよび-γ-η-ノナラクトンが得られた。
Kazuyoshi Fujiwara
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Association Between Serum Methylmalonic Acid (A Marker of Mitochondrial Dysfunction) and Serum Neurofilament Light Chains in a U.S. Population: a Cross‐Sectional Analysis From NHANES 2013–2014 [PDF]
Brain BehavWei J, Liu Y, Li Y.
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